Results 31 to 40 of about 2,667 (184)

<i>Camellia oleifera</i> Seed Cake Extract Ameliorates Hyperuricemia and Renal Injury by Modulating Uric Acid Metabolism, Nrf2/Keap1 Pathway, and NLRP3 Inflammasome in Mice. [PDF]

Food Sci Nutr
Protective mechanisms of Camellia oleifera seed cake extract (SCE) against hyperuricemia and renal injury via modulation of uric acid metabolism, Nrf2/Keap1 signaling, and NLRP3 inflammasome activation. ABSTRACT Camellia oleifera seed cake is a major byproduct of the oil industry, often underutilized despite its richness in bioactive compounds.
Mai L, Xie Y, Zhang Y, Ni C, Xu Y, Xu L, Lin G, Lin Y, Su Z, Wang J, Ren M.   +10 more
europepmc   +2 more sources

URAT1 inhibition by ALPK1 is associated with uric acid homeostasis. [PDF]

Rheumatology (Oxford, England), 2017
The aim of this study was to identify a protein for urate transporter 1 (URAT1) regulation.The clinical dataset consisted of 492 case-control samples of Han Chinese (104 gout and 388 controls). Three alpha kinase 1 ( ALPK1 ) and SLC22A12 loci associated with high gout risk and uric acid levels were genotyped.
Kuo, T., Huang, C., Tu, H., Ko, A. ; https://orcid.org/0000-0002-2096-1330, Wang, S., Lee, C., Ko, Y.   +6 more
openaire   +3 more sources

Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model

Drug Design, Development and Therapy, 2021
Qiaoping Li,1,* Ziwei Huang,2,* Defu Liu,3 Jingna Zheng,1 Jianhui Xie,4– 6 Jiannan Chen,1 Huifang Zeng,2 Ziren Su,1 Yucui Li1 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of ...
Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y   +8 more
doaj  

Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods [PDF]

Evidence-Based Complementary and Alternative Medicine, 2021
Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing ...
Ying Chen, Ruya You, Ke Wang, Yousheng Wang   +3 more
openaire   +2 more sources

Transporter-centric view of urate metabolism: From genome-wide association study to pathophysiology

Journal of Physical Fitness and Sports Medicine, 2012
While urate is an important anti-oxidant molecule in the body, high plasma levels of urate cause morbidity including urate crystal deposition in joints (gout) and stone formation in the urinary tract. Because urate is an end product of purine metabolism,
Hiroyuki Sakurai
doaj   +1 more source

Renal Hypouricemia 1: Rare Disorder as Common Disease in Eastern Slovakia Roma Population

Biomedicines, 2021
Renal hypouricemia (RHUC) is caused by an inherited defect in the main reabsorption system of uric acid, SLC22A12 (URAT1) and SLC2A9 (GLUT9). RHUC is characterized by a decreased serum uric acid concentration and an increase in its excreted fraction ...
Blanka Stiburkova, Jana Bohatá, Kateřina Pavelcová, Velibor Tasic, Dijana Plaseska-Karanfilska, Sung-Kweon Cho, Ludmila Potočnaková, Jana Šaligová   +7 more
doaj   +1 more source

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

, 2020
The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact of FAs on the handling of urate, the end-product of human purine metabolism, in the body.
Yu Toyoda, Naoyuki Kobayashi, Hiroki Saito, Ami Ota-Kontani, Hiroshi Suzuki, Youichi Tsuchiya, Hiroshi Hirata, Hiroshi Miyata, Tappei Takada   +8 more
core   +1 more source

Identification of Inhibitory Activities of Dietary Flavonoids against URAT1, a Renal Urate Re-Absorber: In Vitro Screening and Fractional Approach Focused on Rooibos Leaves

, 2022
Hyperuricemia, a lifestyle-related disease characterized by elevated serum urate levels, is the main risk factor for gout; therefore, the serum urate-lowering effects of human diets or dietary ingredients have attracted widespread interest.
Yu Toyoda, Hiroki Saito, Ami Ota-Kontani, Hiroshi Suzuki, Youichi Tsuchiya, Hiroshi Hirata, Tappei Takada   +6 more
core   +1 more source

Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids

Foods, 2022
Hyperuricemia (HUA), characterized by abnormal serum uric acid (UA) levels, is recognized as an important risk factor for hyperuricemic nephropathy (HN), which is strongly linked to gut microbiota.
Yongmei Li, Lu Li, Jinhong Tian, Fengxin Zheng, Hui Liao, Zean Zhao, Yanyu Chen, Jianxin Pang, Ting Wu   +8 more
doaj   +1 more source

Mechanism of high affinity inhibition of the human urate transporter URAT1 [PDF]

Scientific Reports, 2016
AbstractGout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. We exploited affinity differences between the human and rat transporters to map inhibitor binding sites in URAT1. Human-rat transporter chimeras revealed that human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are ...
Philip K. Tan, Traci M. Ostertag, Jeffrey N. Miner   +2 more
openaire   +2 more sources