Results 11 to 20 of about 2,667 (184)

Clinical and functional characterization of URAT1 variants. [PDF]

PLoS ONE, 2011
Idiopathic renal hypouricaemia is an inherited form of hypouricaemia, associated with abnormal renal handling of uric acid. There is excessive urinary wasting of uric acid resulting in hypouricaemia.
Velibor Tasic, Ann Marie Hynes, Kenichiro Kitamura, Hae Il Cheong, Vladimir J Lozanovski, Zoran Gucev, Promsuk Jutabha, Naohiko Anzai, John A Sayer   +8 more
doaj   +6 more sources

Molecular basis of the urate transporter URAT1 inhibition by gout drugs

Nature Communications
Hyperuricemia is a condition when uric acid, a waste product of purine metabolism, accumulates in the blood. Untreated hyperuricemia can lead to crystal formation of monosodium urate in the joints, causing a painful inflammatory disease known as gout ...
Yang Suo, Justin G. Fedor, Han Zhang, Kalina Tsolova, Xiaoyu Shi, Kedar Sharma, Shweta Kumari, Mario Borgnia, Peng Zhan, Wonpil Im, Seok-Yong Lee   +10 more
doaj   +5 more sources

Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1 [PDF]

BMJ Open, 2015
Objectives Human urate transporter 1 (URAT1) is a member of the organic anion transporter family (SLC22A12) that primarily regulates the renal tubular reabsorption of uric acid. This case–control study was designed to analyse whether hURAT1 might also be a candidate gene for hyperuricaemia or hypouricaemia.
Cho, Sung Kweon, Kim, Soriul, Chung, Jae-Yong, Jee, Sun Ha   +3 more
openaire   +5 more sources

Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1

Biomolecules, 2020
The relationship of uric acid with macrophages has not been fully elucidated. We investigated the effect of uric acid on the proinflammatory ability of human macrophages and then examined the possible molecular mechanism involved. Primary human monocytes
Camilo P. Martínez-Reyes, Aarón N. Manjarrez-Reyna, Lucia A. Méndez-García, José A. Aguayo-Guerrero, Beatriz Aguirre-Sierra, Rafael Villalobos-Molina, Yolanda López-Vidal, Karen Bobadilla, Galileo Escobedo   +8 more
doaj   +2 more sources

Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout

Scientific Reports, 2017
Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad (RDEA3170), which is currently under evaluation for gout therapy.
Philip K. Tan, Sha Liu, Esmir Gunic, Jeffrey N. Miner   +3 more
doaj   +2 more sources

Molecular mechanism of drug inhibition of URAT1

Nature Communications
Hyperuricemia, characterized by elevated serum urate levels, is a key factor in the pathogenesis of gout. URAT1 is essential for renal urate reabsorption and has emerged as a critical therapeutic target for managing hyperuricemia.
Zhuoya Yu, Tuo Hu, Jiawei Su, Jun Zhao, Renjie Li, Qiao Ma, Qihao Chen, Qinru Bai, Yanli Dong, Pu Yuan, Na Li, Xuejun Cai Zhang, Yan Zhao   +12 more
doaj   +3 more sources

Fucoidan from Laminaria japonica Inhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells

Marine Drugs, 2021
This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS ...
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang   +8 more
doaj   +2 more sources

URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews [PDF]

Nephrology Dialysis Transplantation, 2010
Hereditary renal hypouricemia may be complicated by nephrolithiasis or exercise-induced acute renal failure. Most patients described so far are of Japanese origin and carry the truncating mutation W258X in the uric acid transporter URAT1 encoded by SLC22A12. Recently, we described severe renal hypouricemia in Israeli patients with uric acid transporter
Dinour, Dganit, Bahn, Andrew, Ganon, Liat, Ron, Rotem, Geifman-Holtzman, Ossie, Knecht, Aaron, Gafter, Uzi, Rachamimov, Ruth, Sela, Ben-Ami, Burckhardt, Gerhard, Holtzman, Eliezer J.   +10 more
openaire   +4 more sources

Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway

BMC Cardiovascular Disorders, 2023
Objective Previous studies have revealed associations between hyperuricemia and microvascular diseases, but the association between hyperuricemia and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to elucidate the pathogenesis
Jen-Chun Wang, Shih-Hung Tsai, Hsiao-Ya Tsai, Shing-Jong Lin, Po-Hsun Huang   +4 more
doaj   +2 more sources

Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1

Molecules, 2018
(1) Background: Crude drugs used in traditional Japanese Kampo medicine or folk medicine are major sources of new chemical entities for drug discovery.
Yuusuke Tashiro, Ryo Sakai, Tomoko Hirose-Sugiura, Yukio Kato, Hirotaka Matsuo, Tappei Takada, Hiroshi Suzuki, Toshiaki Makino   +7 more
doaj   +2 more sources