Results 21 to 30 of about 2,667 (184)

Cordycepin, a Characteristic Bioactive Constituent in Cordyceps militaris, Ameliorates Hyperuricemia through URAT1 in Hyperuricemic Mice

Frontiers in Microbiology, 2018
Recently, we've reported the anti-hyperuricemic effects of Cordyceps militaris. As a characteristic compound of C. militaris, we hypothesized that cordycepin may play a role in preventing hyperurecimia.
Tianqiao Yong, Tianqiao Yong, Shaodan Chen, Shaodan Chen, Yizhen Xie, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Chunwei Jiao, Dan Zuo   +10 more
doaj   +3 more sources

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

Nature Communications
High urate levels in circulation lead to the accumulation of urate crystals in joints and ultimately inflammation and gout. The reabsorption process of urate in the kidney by the urate transporter URAT1 plays a pivotal role in controlling serum urate ...
Wenjun Guo, Miao Wei, Yunfeng Li, Jiaxuan Xu, Jiahe Zang, Yuezhou Chen, Lei Chen   +6 more
doaj   +3 more sources

Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways

Cellular Physiology and Biochemistry, 2018
Background/Aims: Zurampic is a US FDA approved drug for treatment of gout. However, the influence of Zurampic on pancreatic β-cells remains unclear. The study aimed to evaluate the effects of Zurampic on high uric acid-induced damage of pancreatic β ...
Ying Xin, Kun Wang, Zhaotong Jia, Tao Xu, Qiang Xu, Chao Zhang, Jia Liu, Rui Chen, Zhongcai Du, Jianjing Sun   +9 more
doaj   +3 more sources

Clinical and Functional Characterization of a Novel URAT1 Dysfunctional Variant in a Pediatric Patient with Renal Hypouricemia

Applied Sciences, 2019
Renal hypouricemia (RHUC) is caused by an inherited defect in the main (reabsorptive) renal urate transporters, URAT1 and GLUT9. RHUC is characterized by decreased concentrations of serum uric acid and an increase in its excretion fraction.
Blanka Stiburkova, Jana Bohata, Iveta Minarikova, Andrea Mancikova, Jiri Vavra, Vladimír Krylov, Zdenek Doležel   +6 more
doaj   +2 more sources

Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

The Journal of Clinical Investigation
BACKGROUND Hyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODS We evaluated the association between ...
Wataru Fujii, Osamu Yamazaki, Daigoro Hirohama, Ken Kaseda, Emiko Kuribayashi-Okuma, Motonori Tsuji, Makoto Hosoyamada, Yuta Kochi, Shigeru Shibata   +8 more
doaj   +2 more sources

A Post-NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout. [PDF]

Microbiologyopen
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Hossain MS, Kim S, Aziz MT, Ahmed I, Shuvo MSH, Yang H, Jang Y, Kim M, Jang S, Kim Y, Oh S, Nam Y, Seo H, Song HY.   +13 more
europepmc   +2 more sources

Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption. [PDF]

Chem Biol Drug Des
The graphical abstract illustrates the action mechanisms through which PPE alleviates HUA by inhibiting XOD activity, and by suppressing the PI3K‐AKT signaling pathway to downregulate the expression of the urate reabsorption transporters URAT1 and GLUT9, thereby promoting renal UA excretion and attenuating renal injury.
Yin Z, Liang S, Yang G, Guo P, Wang C, Han Q, Song X.   +6 more
europepmc   +2 more sources

Hirudin Attenuates Uric Acid-Induced Renal Tubular Injury via TNFRSF6B-Mediated Suppression of NF-κB Signaling. [PDF]

Pharmacol Res Perspect
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Zhao Y, Qin Y, He L, Luo H, Mo Y, Zhou W, He H, Zhou G, Liu X.   +8 more
europepmc   +2 more sources

The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia [PDF]

Journal of Clinical Laboratory Analysis, 2021
AbstractBackgroundThis study was designed to evaluate the impact of polymorphisms in the urate transporter 1 (URAT1) gene on the uricosuric action of losartan therapy in hypertensive patients suffering from hyperuricemia.MethodsA MassARRAY approach was used to detect single nucleotide polymorphism (SNP) loci in the URAT1 and CYP2C9 genes (16 and 2 loci,
Liting Wu, Yingchao Fan, Yuan Wang, Zhumeng Li, Delong Mao, Wenfang Zhuang   +5 more
openaire   +2 more sources

How URAT1 inhibitors can shape the future of chronic gout treatment: a narrative review of uricosurics past and present [PDF]

Exploration of Musculoskeletal Diseases
Gout is a common inflammatory arthritis preceded by chronically elevated levels of serum urate. In addition to leading to gouty flares, hyperuricemia can result in stone-like deposits of monosodium urate crystals (tophi) being deposited in joints and ...
Robert T. Keenan, Zancong Shen, Shunqi Yan, Li-Tain Yeh, Michael H. Pillinger   +4 more
doaj   +1 more source