Results 41 to 50 of about 5,281 (177)

Problems of adherence to therapy in patients with gout in real clinical practice

Consilium Medicum
Aim. To evaluate treatment adherence among patients with gout. Materials and methods. One hundred and thirty-eight patients with gout were examined in the Dzhanelidze Saint Petersburg Research Institute of Emergency Care; 89.9% of them are men and 10 ...
Elena V. Shchemeleva, Elena A. Skorodumova   +1 more
doaj   +1 more source

Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy

Acta Biomedica Scientifica, 2021
Background. Gout is frequently accompanied by hypertension, obesity, and/or impaired glucose tolerance, which are often complicated with heavy smoking and dietary violations, especially in male patients.Objective.
J. Chen, P. Zhou, W. Tan, M. Zheng, N. Y. Oshmianska   +4 more
doaj   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Prospects of anti-inflammatory and urate-lowering therapy of gout: A vector from the past to the future

Научно-практическая ревматология, 2022
The article provides an overview of new and promising drugs aimed at anti-inflammatory and urate-lowering therapy of gout, both already registered and used in clinical practice, and at the stages of implementation or clinical research and demonstrating ...
A. A. Garanin, N. L. Novichkova, N. L. Novichkova   +2 more
doaj   +1 more source

Clinical Relevance and Diagnostic Utility of Standard Serum Biomarkers in Advanced Chronic Kidney Disease: A Single‐Center Observational Study From Bangladesh

iLABMED, EarlyView.
This study evaluated conventional and emerging biochemical markers for assessing chronic kidney disease (CKD) progression in Bangladeshi patients elevated serum uric acid and parathyroid hormone levels, along with reduced eGFR, vitamin D, and albumin levels, were significantly associated with CKD, highlighting their potential as cost‐effective early ...
Fazlul Haque, Md. Samiul Islam, Nafsoon Rahman, Ayub Zawad, Sadia Afrin, Pulak Kanti Palit, Tanjil Hasan, Md. Isahak Ali, Shafin Ahmed, Akram Hossain, Marina Khatun, Tabassuma Marzia Prome, Md. Shah Alam, Ashekul Islam   +13 more
wiley   +1 more source

Stimuli‐responsive hydrogels: An intelligent tool for wound management

Interdisciplinary Medicine, EarlyView.
For chronic and complex wounds, this review focuses on intelligent hydrogels capable of responding to wound microenvironmental cues (e.g., pH, enzymes) or external stimuli (e.g., light, electricity). These advanced materials enable the dynamic regulation of drug release and real‐time monitoring of healing progression, thereby offering innovative ...
Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li   +10 more
wiley   +1 more source

Pharmacotherapy of gout – modern approaches and prospects

Современная ревматология, 2021
The article discusses modern approaches to the gout treatment, presented in foreign and domestic clinical guidelines. While the use of urate-lowering therapy for gout is a necessary and highly effective strategy, in the case of asymptomatic hyperuricemia,
P. A. Lebedev, A. A. Garanin, N. L. Novichkova   +2 more
doaj   +1 more source

Serum Urate Monitoring Among Older Adults With Gout: Initiating Urate‐Lowering Therapy in Ontario, Canada

Arthritis Care & Research, 2023
ObjectiveTo assess the proportion of, and factors associated with, older adults with gout receiving a serum urate (SUA) test after starting urate‐lowering therapy (ULT).MethodsWe performed a population‐based retrospective cohort study in Ontario, Canada in patients ages ≥66 years with gout, newly dispensed ULT between 2010 and 2019.
Timothy S. H. Kwok, Bindee Kuriya, Gillian Hawker, Ping Li, Gregory Choy, Jessica Widdifield   +5 more
openaire   +2 more sources

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice

Frontiers in Medicine, 2020
Limitations in efficacy and/or tolerance of currently available urate-lowering therapies (ULTs), such as oral xanthine oxidase inhibitors, uricosurics, and intravenous uricase agents contribute to the development of refractory gout.
Kateryna Pierzynowska, Kateryna Pierzynowska, Kateryna Pierzynowska, Aditi Deshpande, Nadiia Mosiichuk, Robert Terkeltaub, Paulina Szczurek, Eduardo Salido, Stefan Pierzynowski, Stefan Pierzynowski, Stefan Pierzynowski, Danica Grujic   +11 more
doaj   +1 more source