Results 141 to 150 of about 114,454,660 (263)

Novel ABCA1 mutations in Tangier disease associated with early‐onset type 2 diabetes: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Tangier disease (TD) is a rare disorder caused by mutations in the ATP‐binding cassette transporter A1 (ABCA1) gene with autosomal recessive inheritance and is characterized by extremely low high‐density lipoprotein cholesterol (HDL‐C) and premature atherosclerosis.
Makoto Wada, Naoko Saito‐Sato, Masaki Tanaka, Junko Nomoto, Aki Watanabe, Masayuki Kuroda, Yoshiro Maezawa, Tetsuta Sato, Yusuke Yagyu, Shuji Toriumi, Amika Kajiyama, Takahide Hashimoto, Naoki Ohtake, Masaya Yamaga, Tomohiko Yoshida, Shoji Tsuji, Minoru Takemoto   +16 more
wiley   +1 more source

FUNCTIONAL CHARACTERIZATION OF URIC ACID TRANSPORTER 1 (Urat1) IN RATS

Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 2008
Mamada, Hideaki, Sato, Masanobu, Shimada, Sho, Shirasaka, Yoshiyuki, Kato, Yukio, Tamai, Ikumi   +5 more
openaire   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

CHANGE IN URIC ACID LEVEL IN A DIETARY INTERVENTION TRIAL IN POST-MENOPAUSAL WOMEN

openAbstract: Back ground: Uric acid, which is produced when purine is broken down in the body, plays a crucial role in both health and disease. Elevated levels of uric acid have been linked to several conditions, such as gout, kidney stones, and ...
ZANDI, POUYA
core  

Effect of ABCG2 allelic variants on the transport of uric acid [PDF]

, 2019
Uric acid is a main metabolite of purine degradation in humans and in higher primates. Its increased plasmatic level is called hyperuricemia and may be the cause of gout and many other similar diseases.
Vávra, Jiří
core  

Causal Effects of Type 2 Diabetes Mellitus on Chronic Periodontitis and the Mediating Role of Oxidative Stress: Evidence From Mendelian Randomization and Mediation Analysis

Oral Diseases, EarlyView.
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of chronic periodontitis, but genetic evidence and oxidative stress‐related pathways remain unclear. Objective This study assessed the genetically inferred association between T2DM and chronic periodontitis, evaluated oxidative stress biomarkers as potential ...
Mengjie Kong, James Kit Hon Tsoi, Kang Li, Cynthia Kar Yung Yiu   +3 more
wiley   +1 more source

Of mice and men—The emerging oral–gut–brain axis of health and disease

Periodontology 2000, EarlyView.
Abstract Objectives Oral health's inextricable links to systemic health are highlighted by the emerging oral–gut–brain axis and other well‐known axes. There is growing evidence of a complex oral–gut–brain axis linking mouth and gut microbiomes with the central nervous system.
Yvonne L. Hernandez‐Kapila, Daniel J. Weisenberger   +1 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Therapeutic potential of okra (Abelmoschus esculentus) in dysglycaemia and metabolic dysfunction: A systematic review and meta‐analysis across the diabetes spectrum

Experimental Physiology, EarlyView.
Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari, Helia Mardani, Mohammad Amin Karimi, MohammadHossein Sahami Gilan, Helia Hemmat, Fatemeh Shoja, Nooshin Enayati Soofi, Ghazaleh Eslamian   +7 more
wiley   +1 more source