Results 231 to 240 of about 114,454,660 (263)

Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System [PDF]

Cells, 2022
Background: Hyperuricemia is a common laboratory finding in pregnant women compromised by preeclampsia. A growing body of evidence suggests that uric acid is involved in the pathogenesis of preeclampsia.
Marc Baumann, Bruno Stieger, Christiane Albrecht   +2 more
exaly   +4 more sources

Effect of Fenofibrate on Uric Acid Metabolism and Urate Transporter 1

Internal Medicine, 2010
To examine the effects of fenofibrate, an antilipotropic drug, on uric acid metabolism in healthy male subjects and on urate transporter 1 (URAT1).Fenofibrate was administered to nine male volunteers at a dose of 300 mg (corresponding to 200 mg of micronized fenofibrate), and the metabolic parameters of uric acid were investigated for more than 12 ...
Kimiyoshi Ichida, Iwao Ohno, Hitoshi Endou   +2 more
exaly   +4 more sources

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Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter 1

Drug Metabolism and Disposition, 2023
Urate transporter 1 (URAT1) is a transporter responsible for uric acid (UA) reabsorption by renal proximal tubules and a pharmacological target of uricosuric agents. Probenecid and benzbromarone have been used as uricosuric agents, while dotinurad was recently approved in Japan.
Kazuki Fujita, Qiunan Zhu, Hiroshi Arakawa, Yoshiyuki Shirasaka, Ikumi Tamai   +4 more
openaire   +2 more sources

Uric Acid Relates to Dopamine Transporter Availability in Parkinson's Disease

Acta Neurologica Scandinavica, 2015
Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers.
Marina Picillo, Raffaele Palladino, Maria Teresa Pellecchia   +2 more
exaly   +2 more sources

Human Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure–Activity Relationship (SAR) Study

Nucleosides, Nucleotides and Nucleic Acids, 2011
The current study describes the chemical synthesis of a series of (2-ethylbenzofuran-3-yl)(substituted-phenyl)methanone compounds and their subsequent in vitro testing via oocytes expressing hURAT1. The experimental data support the notion that a potent hURAT1 inhibitor requires an anion (i.e., a formal negative charge) to interact with the positively ...
H Endou
exaly   +3 more sources

Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2017
This letter presents synthesis and structure-activity relationship study of sulfonamide derivatives as inhibitors of Human Uric Acid Transporter 1 (hURAT1). Among all tested sulfonamide derivatives, compounds 9b, 16i and 19b exhibited excellent inhibition activity with IC50 value of 10, 2, and 83nM, respectively.
Xintuo, Yang, Xuehai, Pang, Lei, Fan, Xinghai, Li, Yuanwei, Chen   +4 more
openaire   +2 more sources

Design, synthesis and biological activity of tetrazole-bearing uric acid transporter 1 inhibitors

Chemical Research in Chinese Universities, 2017
Systematic structure-activity relationship(SAR) exploration of a moderately active tetrazole-bearing lesinurad-based hit 1f led to the discovery of a potent uric acid transporter 1(URAT1) inhibitor 1i, which possessed a novel molecular skeleton and was 11-fold more potent than the parent lesinurad against human URAT1 in-vitro (IC50=0.66 μmol/L for 1i ...
Wenqing Cai, Wei Liu, Yafei Xie, Jingwei Wu, Yuqiang Liu, Changying Liu, Weiren Xu, Lida Tang, Jianwu Wang, Guilong Zhao   +9 more
openaire   +1 more source

Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout

Medicinal Chemistry, 2017
Gout is the most common inflammatory arthritis, which, if left untreated or inadequately treated, will lead to joint destruction, bone erosion and disability due to the crystal deposition. Uric acid transporter 1 (URAT1) was the promising therapeutic target for urate-lowering therapy.The goal of this work is to understand the structure-activity ...
Xiansheng, Zhang, Jingwei, Wu, Wei, Liu, Yuqiang, Liu, Yafei, Xie, Qian, Shang, Zhixing, Zhou, Weiren, Xu, Lida, Tang, Jianwu, Wang, Guilong, Zhao   +10 more
openaire   +2 more sources

The association between genotypes of urate transporter-1, Serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study

Clinical and Experimental Nephrology, 2019
The urate transporter-1 (URAT1) is crucial in developing hyperuricemia via reabsorption of uric acid in renal tubules, and its function is regulated by several single nucleotide polymorphisms (SNPs) within SLC22A12 gene encoding URAT1. This study investigated whether the genetic predisposition of URAT1 is associated with the mortality in general ...
Soichiro Kon, Tsuneo Konta, Kazunobu Ichikawa, Masafumi Watanabe, Hidenori Sato, Kenichi Ishizawa, Yoshiyuki Ueno, Hidetoshi Yamashita, Takamasa Kayama   +8 more
openaire   +2 more sources