Results 241 to 250 of about 114,454,660 (263)
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Clinical and Experimental Nephrology, 2011
Familial renal hypouricemia is a hereditary disease characterized by extraordinary high renal uric acid (UA) clearance and is associated with acute renal failure (ARF). A 17-year-old Japanese male developed ARF after anerobic exercise. Renal function improved completely after approximately 2 weeks of hydration treatment.
Ayami, Ochi +8 more
openaire +2 more sources
Familial renal hypouricemia is a hereditary disease characterized by extraordinary high renal uric acid (UA) clearance and is associated with acute renal failure (ARF). A 17-year-old Japanese male developed ARF after anerobic exercise. Renal function improved completely after approximately 2 weeks of hydration treatment.
Ayami, Ochi +8 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2016
This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat,
Jianbiao, Peng +10 more
openaire +2 more sources
This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat,
Jianbiao, Peng +10 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2019
As a part of our ongoing research to develop novel URAT1 inhibitors, 19 compounds (1a-1s) based on carboxylic acid bioisosteres were synthesized and tested for in vitro URAT1 inhibitor activity (IC50). The structure-activity relationship (SAR) exploration led to the discovery of a highly potent novel URAT1 inhibitor 1g, which was 225-fold more potent ...
Jing-Wei, Wu +6 more
openaire +2 more sources
As a part of our ongoing research to develop novel URAT1 inhibitors, 19 compounds (1a-1s) based on carboxylic acid bioisosteres were synthesized and tested for in vitro URAT1 inhibitor activity (IC50). The structure-activity relationship (SAR) exploration led to the discovery of a highly potent novel URAT1 inhibitor 1g, which was 225-fold more potent ...
Jing-Wei, Wu +6 more
openaire +2 more sources
Molecular Pharmacology
Various types of drugs can affect serum urate levels as side effects. Although these drugs are used to treat different diseases, they might share a structural component that acts on a common target to affect urate levels. Human urate transporter 1 (URAT1) plays an essential role in urate reabsorption at the renal proximal tubule and thus might be a ...
Misa Sayama +5 more
openaire +2 more sources
Various types of drugs can affect serum urate levels as side effects. Although these drugs are used to treat different diseases, they might share a structural component that acts on a common target to affect urate levels. Human urate transporter 1 (URAT1) plays an essential role in urate reabsorption at the renal proximal tubule and thus might be a ...
Misa Sayama +5 more
openaire +2 more sources
European Journal of Medicinal Chemistry
We report the design and synthesis of a series of proline-derived quinoline formamide compounds as human urate transporter 1 (URAT1) inhibitors via a ligand-based pharmacophore approach. Structure-activity relationship studies reveal that the replacement of the carboxyl group on the polar fragment with trifluoromethanesulfonamide and substituent ...
Shengnan Li +15 more
openaire +2 more sources
We report the design and synthesis of a series of proline-derived quinoline formamide compounds as human urate transporter 1 (URAT1) inhibitors via a ligand-based pharmacophore approach. Structure-activity relationship studies reveal that the replacement of the carboxyl group on the polar fragment with trifluoromethanesulfonamide and substituent ...
Shengnan Li +15 more
openaire +2 more sources
Uric Acid Transport, Transporters, and Their Pharmacological Targeting
Acta Physiologica, 2023Orson W. Moe, Emmanuel A Adomako
exaly
Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia
Frontiers in Pharmacology, 2021Xiao-ming Meng, Heng Wang, Juan Jin
exaly
Sodium-Glucose Co-Transporter-2 (SGLT-2) Inhibitors and Uric Acid: More Good News!
Journal of Diabetes and Its Complications, 2023Manfredi Rizzo +2 more
exaly
The Effect of Polymorphism of Uric Acid Transporters on Uric Acid Transport
Journal of Nephrology, 2019Yazhuo Li, Fang Zhao, Rui Liu
exaly