Results 121 to 130 of about 2,782,099 (278)

Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Communications Biology
Decreased renal uric acid excretion is a major contributor to hyperuricemia (HUA), but its underlying mechanism remains unclear. Here, we identify cathepsin B (CTSB) as a key regulator of urate handling in HUA.
Huagang Lin, Linjing Nie, Deping Wu, Dexian Zhang, Rui Peng, Sijie Tao, Zhibin Ye, Sibo Zhu, Maoqing Ye, Jing Xiao   +9 more
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Skeletal Muscle Purine Nucleotide Degradation and Atrophy: Cause or Consequence of Increased Uric Acid Production

, 2023
Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associated with skeletal muscle atrophy. Uric acid is generated by xanthine oxidoreductase (XOR) and XOR inhibitors can partially attenuate muscle atrophy. Whether
Miller, Spencer Graham, NC DOCKS at East Carolina University   +1 more
core   +1 more source

Investigating the mechanisms of lactulose on gut health and uric acid metabolism in geese via transcriptomics

Scientific Reports
In recent years, the escalating incidence of goose gout has inflicted severe economic losses on the goose industry. This research aimed to investigate the impact of lactulose on both intestinal health and uric acid metabolism in geese, as well as to ...
Pengfei Ye, Xiaorong He, Xueqi Zhu, Jie Zhu, Xiaoxue Wang, Shiyan Cao, Yu Meng, Jing Li, Lei Zhao   +8 more
doaj   +1 more source

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

Small, EarlyView.
A fenestrated microneedle biosensor enables continuous transdermal monitoring of lactate in interstitial fluid while protecting the functional sensing interface during insertion into the skin. The platform delivers sensitive electrochemical lactate detection and distinguishes metabolic profiles in healthy and type 2 diabetic‐obese mice, and captures ...
Masoud Khazaei, Ali‐Reza Shokouhi, Parham Sahandi Zangabad, Victor J. Cadarso, Muamer Dervisevic, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Uric Acid and Cardiovascular Events: A Mendelian Randomization Study

, 2015
Obesity and diets rich in uric acid-raising components appear to account for the increased prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension, diabetes mellitus, CKD, and cardiovascular disease are also increasing ...
Krämer, Bernhard K, Ritz, Eberhard, Silbernagel, Günther, Huang, Jie, Grammer, Tanja B, März, Winfried, Kleber, Marcus E, Delgado, Graciela, Huang J, Ritz E, Silbernagel G, Krämer BK, März W, Kleber ME, Delgado G, Grammer TB   +15 more
core   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

Microfluidic Molecular Diagnostic Chips: Functional Modules, Integration Strategies, and Emerging Applications

Small Methods, EarlyView.
This comprehensive review delivers an engineering‐centric analysis of microfluidic molecular diagnostic chips, breaking them down into foundational modules from fluid manipulation to bio‐sensing. Beyond chip design, it evaluates sample‐to‐answer integration strategies and commercial readiness levels.
Donghoon Koo, Egor Kokin, Sangyul Baik, Chanyong Park, Minji Kim, Jeongmin Kim, Ryungeun Song, Hosub Lim   +7 more
wiley   +1 more source

Guiling prescription attenuates hyperuricemia via multi-target regulation of uric acid metabolism, renal protection, and inflammation: insights from metabolomics and network pharmacology

Frontiers in Nutrition
BackgroundThis study aims to evaluate the efficacy of Guiling Prescription (GP)—a medicinal food homologous formula—in hyperuricemic rats, its effects on uric acid excretion and renal function, and to clarify the metabolic mechanisms involved in GP's ...
YuKun Wang, YuKun Wang, YuKun Wang, RenJie Ding, RenJie Ding, RenJie Ding, Yaxuan Guo, Yaxuan Guo, Yaxuan Guo, TianHui Zhou, TianHui Zhou, TianHui Zhou, Huichun Zhao, HuiWu Liu, XueMei Qin, XueMei Qin, XueMei Qin, XiaoXia Gao, XiaoXia Gao, XiaoXia Gao   +19 more
doaj   +1 more source

Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter

, 2019
Background: Soluble uric acid stimulates vascular smooth muscle cell (VSMC) proliferation by activating mitogen-activated protein kinases, and stimulating COX-2 and PDGF synthesis. The mechanism by which uric acid enters the VSMC is not known.
강덕희
core   +1 more source