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Uric Acid Transport, Transporters, and Their Pharmacological Targeting
Acta Physiologica, 2023 Abstract Knowledge of uric acid (UA) crystallopathies preceded the identification of this compound. How the body handles and transports UA proved even more elusive. Over several decades, advances in molecular phenotyping have illuminated this hitherto nebulous field. Closely parallel to the characterization of the transport mechanisms
Orson W. Moe, Emmanuel A Adomako
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Current Opinion in Nephrology and Hypertension, 2003
The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A, Rafey +3 more
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The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A, Rafey +3 more
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The effect of polymorphism of uric acid transporters on uric acid transport
Journal of Nephrology, 2018Abstract The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination.
Ze Wang +9 more
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Expression and Purification of a Functional Uric Acid–Xanthine Transporter (UapA)
Protein Expression and Purification, 2010 The Nucleobase-Ascorbate Transporters (NATs) family includes carriers with fundamental functions in uptake of key cellular metabolites, such as uric acid or vitamin C. The best studied example of a NAT transporter is the uric acid-xanthine permease (UapA) from the model ascomycete Aspergillus nidulans.
Bernadette Byrne, George Diallinas
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Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats
Drug Metabolism and Pharmacokinetics, 2019The inhibitor of uric acid reabsorptive transporter URAT1 in kidney is drawing attention as a drug target for hyperuricemia. However, it is difficult to evaluate efficacy of URAT1 inhibitors in vivo using laboratory animals due to species difference in uric acid metabolism.
Hiroshi Arakawa +4 more
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Effect of Fenofibrate on Uric Acid Metabolism and Urate Transporter 1
Internal Medicine, 2010 To examine the effects of fenofibrate, an antilipotropic drug, on uric acid metabolism in healthy male subjects and on urate transporter 1 (URAT1).Fenofibrate was administered to nine male volunteers at a dose of 300 mg (corresponding to 200 mg of micronized fenofibrate), and the metabolic parameters of uric acid were investigated for more than 12 ...
Kimiyoshi Ichida +2 more
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Is uric acid transported by the hippurate transport system?
Pfl�gers Archiv European Journal of Physiology, 1974Experiments were designed to determine whether renal excretion of uric acid is achieved by the same mechanism as for renal tubular excretion of hippurates and related organic acids. Surviving slices of rabbit kidney cortex were unable to accumulate C14-urate by a concentrative mechanism.
Vernon D. Jones +3 more
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Influence of inorganic electrolytes and ouabain on uric acid transport
American Journal of Physiology-Legacy Content, 1965The importance of certain inorganic electrolytes in the transport of some organic acids by the kidney has been demonstrated. The present study was undertaken to evaluate further the transport characteristics for uric acid. Slices of rabbit kidney cortex were found to accumulate urate with a dependency on the medium potassium concentration.
W O, BERNDT, E C, BEECHWOOD
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