Results 11 to 20 of about 99,858 (332)

Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases

Frontiers in Physiology
Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a concentration higher than the other nucleosides. As a simple metabolite, uridine plays a pivotal role in various biological processes. In addition to nucleic acid synthesis,
Yueyuan Yang, Yahong Ye, Yingfeng Deng, Ling Gao   +3 more
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Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel

Scientific Reports, 2021
The effect of uridine on the myocardial ischemic and reperfusion injury was investigated. A possible mechanism of its cardioprotective action was established.
Irina B. Krylova, Elena N. Selina, Valentina V. Bulion, Olga M. Rodionova, Natalia R. Evdokimova, Natalia V. Belosludtseva, Maria I. Shigaeva, Galina D. Mironova   +7 more
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Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice. [PDF]

PLoS ONE, 2016
Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress. Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced liver lipid accumulation.
Yasuyo Urasaki, Giuseppe Pizzorno, Thuc T Le   +2 more
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Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario

Life, 2020
The availability of nucleotides on the early Earth is of great significance for the origin of a self-replicating system capable of undergoing evolution. We hereby report the successful phosphorylation reactions of the nucleoside uridine under heating in ...
Maheen Gull, Arthur Omran, Tian Feng, Matthew A. Pasek   +3 more
doaj   +2 more sources

Indispensable residue for uridine binding in the uridine-cytidine kinase family

Biochemistry and Biophysics Reports, 2017
Uridine-cytidine kinase (UCK), including human UCK2, are a family of enzymes that generally phosphorylate both uridine and cytidine. However, UCK of Thermus thermophilus HB8 (ttCK) phosphorylates only cytidine.
Fumiaki Tomoike, Noriko Nakagawa, Kenji Fukui, Takato Yano, Seiki Kuramitsu, Ryoji Masui   +5 more
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Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis. [PDF]

PLoS ONE, 2015
Uridine has earlier been show to down modulate inflammation in models of lung inflammation. The aim of this study was to evaluate the anti-inflammatory effect of uridine in arthritis.Arthritis was induced by intra-articular injection of mBSA in the knee ...
Sudeep Chenna Narendra, Jaya Prakash Chalise, Mattias Magnusson, Srinivas Uppugunduri   +3 more
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Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

Scientific Reports, 2017
Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation.
Manish Kumar Jeengar, Dinesh Thummuri, Mattias Magnusson, V. G. M. Naidu, Srinivas Uppugunduri   +4 more
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Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. [PDF]

PLoS ONE, 2014
Purines and pyrimidines are complementary bases of the genetic code. The roles of purines and their derivatives in cellular signal transduction and energy metabolism are well-known.
Yasuyo Urasaki, Giuseppe Pizzorno, Thuc T Le   +2 more
doaj   +2 more sources

Uridine Diphosphoacetylglucosamine Pyrophosphorylase

Journal of Biological Chemistry, 1959
Jack L. Strominger, Mildred S. Smith
openalex   +4 more sources

Studies on uridine-diphosphate-glucose [PDF]

Biochemical Journal, 1952
Blanco y ...
Antonella Paladini, Luis F. Leloir
openalex   +6 more sources