Results 81 to 90 of about 96,444 (318)

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Synthese des 18F-markierten Coenzyms Uridindiphosphatglucose als Basis für die 18F-Glykosylierung von Glykoproteinen [PDF]

, 2000
The chemo-enzymatic radiosynthesis of no carrier added (n.c.a.) uridine diphospho-2-deoxy- 2-[$^{18}$F]fluoro-$\alpha$-D-glucose (UDP-[$^{18}$F]FGlc) was developed.
Prante, Olaf
core  

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Chemistry &Biodiversity, EarlyView.
ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos, Marie Demonceaux, Lucia Emanueli Schimith, Marine Goux, Claude Solleux, Ana Luiza Muccillo‐Baisch, Bruno Dutra Arbo, Corinne Andre‐Miral, Mariana Appel Hort   +8 more
wiley   +1 more source

Development of icterus gravis in a preterm infant with G71R UGT1A1 polymorphism [PDF]

, 2013
BACKGROUND: Uridine diphosphate-glucuronosyltransferase (UGT) gene family is involved in the detoxification of biomaterials and drugs in the liver. Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.
Akimune Kaga, Haruo Usuda, Muneyuki Tanabu, Sachiko Saito, Shigeo Kure, Susumu Kanda, Takuma Matsuki, Yohei Watanabe, Yukimune Ohkubo, Yutaka Suzuki   +9 more
core   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2013
Uridine diphosphate (UDP) is a proinflammatory nucleotide implicated in inflammatory bowel disease. Intestinal alkaline phosphatase (IAP) is a gut mucosal defense factor capable of inhibiting intestinal inflammation.
Angela K. Moss, Sulaiman R. Hamarneh, M. R. Mohamed, Sundaram Ramasamy, Halim Yammine, Palak Patel, K. Kaliannan, S. N. Alam, Nur Muhammad, O. Moaven, Abeba Teshager, Nondita S. Malo, S. Narisawa, José Luis Millán, H. Shaw Warren, E. Hohmann, Madhu S Malo, R. Hodin   +17 more
semanticscholar   +1 more source

Recent advances in the chemical synthesis of sugar-nucleotides [PDF]

, 2017
No ...
Ahmadipour, S, Miller, GJ
core   +2 more sources

Corynebacterium glutamicum for Microbial Production of Chitin Oligosaccharides Using Modular Engineering

Food Bioengineering, EarlyView.
Based on metabolic engineering, a chitin oligosaccharide (CHOSs) synthesis metabolic pathway was constructed in Corynebacterium glutamicum, establishing a cell factory for CHOSs synthesis through the selection of chassis cells and key enzymes. Utilizing this framework, multiple strategies were employed to enhance the GlcNAc and UDP‐GlcNAc synthesis ...
Chen Deng, Ruijie Xin, Xingjian Li, Liqiang Fan, Yongjun Qiu, Liming Zhao   +5 more
wiley   +1 more source

Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone [PDF]

, 2013
The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of
Altschul, Anthony Flinn, Bellu, Bonsor, Cantarel, Coutinho, Doerks, Gary W. Black, Grille, Hansen, Hashimoto, Julian S. Northen, Justin J. Perry, Laemmli, Lemmon, Li, Lynn G. Dover, Madina, Madina, Meng Zhang, O'Reilly, Oku, Palcic, Poppenberger, Rabbani, Robertson, Vatsala Malik, Warnecke, Weijers, Yang, Zea   +30 more
core   +1 more source

Deciphering of nutritional profile, therapeutic potential, and networking of bioactive compounds of Moringa oleifera: A comprehensive review

Food Biomacromolecules, EarlyView.
The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar, Sunita Khatak, Vandana, Adarsh Kumar Shukla, Surbhi Panwar, Ashwani Kumar   +5 more
wiley   +1 more source