Results 41 to 50 of about 66,671 (164)

Zoledronate Derivatives as Potential Inhibitors of Uridine Diphosphate-Galactose Ceramide Galactosyltransferase 8:A Combined Molecular Docking and Dynamic Study [PDF]

, 2016
Krabbe's disease is a neurodegenerative disorder caused by deficiency of galactocerebrosidase activity that affects the myelin sheath of the nervous system, involving dysfunctional metabolism of sphingolipids. It has no cure. Because substrate inhibition
Cardile, Venera, Graziano, Adriana Carol Eleonora, Pannuzzo, Giovanna, Avola, Rosanna, Pannuzzo, Martina, Masman, Marcelo Fabricio   +5 more
core   +2 more sources

Developmental aspects of uridine diphosphate galactose 4-epimerase in rat intestine [PDF]

Biochemical Journal, 1971
Kinetic and developmental characteristics of rat intestinal UDP-galactose 4-epimerase activity have been examined. The enzyme in the adult rat had a Vmax. value 2–3 times higher than that of the newborn animal, but the Km values for the enzyme in the newborn and adult rat were the same (0.17mm). No differences in epimerase activity were found along the
A, Weinstein, O, Koldovský, S, Segal
openaire   +2 more sources

Evolution of milk oligosaccharides and lactose: a hypothesis

Animal, 2012
Mammalian milk or colostrum contains up to 10% of carbohydrate, of which free lactose usually constitutes more than 80%. Lactose is synthesized within lactating mammary glands from uridine diphosphate galactose (UDP-Gal) and glucose by a ...
T. Urashima, K. Fukuda, M. Messer
doaj   +1 more source

Lactogenesis in the rat. Metabolism of uridine diphosphate galactose by mammary gland [PDF]

Biochemical Journal, 1968
1. Lactose synthetase activity in the rat mammary gland increases during the last day of pregnancy from an essentially zero value. There is a parallel increase of tissue lactose and of glucose 6-phosphate dehydrogenase activity. 2. Mammary-gland homogenates prepared both before and after parturition hydrolyse the lactose precursors glucose 6-phosphate,
openaire   +2 more sources

Increased sugar content impairs pollen fertility and reduces seed-setting in high-photosynthetic-efficiency rice

Crop Journal
Crop yield depends on biomass, which is primarily associated with photosynthesis. We previously demonstrated that two photorespiratory bypasses, i.e., GOC (glycolate oxidase + oxalate oxidase + catalase) and GCGT (glycolate oxidase + catalase ...
Bodi Li, Anyao Huang, Limin Wang, Shuofan Wu, Zheng Xu, Xiaoyuan Chen, Zhisheng Zhang, Xinxiang Peng   +7 more
doaj   +1 more source

Uridine diphosphate glycosyltransferase gene expression profile

, 2023
The relative expression levels of uridine diphosphate glycosyltransferase (UGT) gene in the 3rd instar larvae of Galeruca daurica treated with different sublethal concentrations of ...
Yao Tan (16445055)
core   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

Mechanism-based candidate inhibitors of uridine diphosphate galactopyranose mutase (UGM)

, 2016
Uridine diphosphate-galactopyranose mutase (UGM), an enzyme found in many eukaryotic and prokaryotic human pathogens, catalyzes the interconversion of UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf), the latter being used as the ...
Pinto, BM, Mohan, S, Mahdavi-Amiri, Y, Borrelli, S, Slowski, K, Sanders, DAR   +5 more
core   +1 more source

Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant [PDF]

, 2006
Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. T. brucei hexose transporters are unable to transport galactose, which is instead obtained through the epimerization of UDP ...
Turnock, Daniel C., Ferguson, Michael A. J., Urbaniak, Michael D.   +2 more
core   +5 more sources

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source