Results 31 to 40 of about 66,671 (164)

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Kennedy, Charles, Gurney, Alison M.   +2 more
core   +5 more sources

Ganglioside biosynthesis. Characterization of uridine diphosphate galactose: GM2 galactosyltransferase in Golgiapparatus from rat liver

Journal of Lipid Research, 1976
An enzyme that transfers galactose from UDP-Gal to ganglioside GM2 (Tay-Sachs ganglioside) was concentrated 50 times in Golgi apparatus from rat liver relative to total homogenates.
F E Wilkinson, D J Morré, T W Keenan
doaj   +1 more source

Profiling of intracellular metabolites produced from galactose and its potential for galactosemia research

Orphanet Journal of Rare Diseases, 2018
Background Clinical outcome of patients with a classical presentation of galactosemia (classical patients) varies substantially, even between patients with the same genotype.
Michel van Weeghel, Lindsey Welling, Eileen P. Treacy, Ronald J. A. Wanders, Sacha Ferdinandusse, Annet M. Bosch   +5 more
doaj   +1 more source

Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding

, 2020
The elimination of numerous endogenous compounds and xenobiotics via glucuronidation by uridine-5′-diphosphate glycosyltransferase enzymes (UGTs) is an essential process of the body’s chemical defense system.
Abby C. Collier (6846800), Alexander D. Smith (8602878), Brent D. G. Page (8602881), Michael W. H. Coughtrie (8602884)   +3 more
core   +3 more sources

Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaPStructural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP [PDF]

Open Biology
Host–pathogen interactions frequently depend on key components of the bacterial cell surface, such as capsules and lipopolysaccharides in Gram-negative bacteria.
Miriam Weckener, Audrey Le Bas, Philip N. Ward, Bradley R. Clarke, Peter J. Harrison, Stephen A. McMahon, Huanting Liu, Alice Eddershaw, Andrew M. Giltrap, Els Pardon, Abirami Lakshminarayanan, Jan Steyaert, Benjamin G. Davis, Chris Whitfield, James H. Naismith   +14 more
doaj   +1 more source

Urinary reducing substances in neonatal intrahepatic cholestasis caused by citrin deficiency

Journal of Pediatric and Neonatal Individualized Medicine, 2014
Neonatal cholestasis due to citrin deficiency is an autosomal recessive metabolic disorder caused by mutations in SLC25A13 gene. Mutations in this gene have a relatively high prevalence in East-Asian races compared to European or Afro-Caribbean races ...
Ajmal Kader, Christina Ong, Veena Logarajah, Kong Boo Phua, Ee Shien Tan   +4 more
doaj   +1 more source

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Disease Models & Mechanisms, 2014
Classic galactosemia (CG) is an autosomal recessive disorder resulting from loss of galactose-1-phosphate uridyltransferase (GALT), which catalyzes conversion of galactose-1-phosphate and uridine diphosphate (UDP)-glucose to glucose-1-phosphate and UDP ...
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie   +2 more
doaj   +1 more source

Diphosphate modified antiviral analogues of uridine 5'-diphosphate glucose derivatives

, 2023
Aseries of analogues (IV), (VII), (VIII) of uridine 5′-diphosphate glucose in which the five atom diphosphate bridge has been replaced by other three, five, and six atom bridges is prepared Starting from the compounds (Ia), (V), or (VI) as shown in the ...
Heras, F. G. de las, Alarcón, Balbino, Fernández-Resa, Piedad, San-Félix, Ana, Carrasco, Luis, García-López, M. Teresa   +5 more
core   +1 more source

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Molecules, 2019
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier   +7 more
doaj   +1 more source

Do Galactolipid Synthases Play a Key Role in the Biogenesis of Chloroplast Membranes of Higher Plants?

Frontiers in Plant Science, 2018
A unique feature of chloroplasts is their high content of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), which constitute up to 80% of their lipids.
Joana Rocha, Joana Rocha, Milène Nitenberg, Milène Nitenberg, Agnès Girard-Egrot, Juliette Jouhet, Juliette Jouhet, Eric Maréchal, Eric Maréchal, Maryse A. Block, Maryse A. Block, Christelle Breton, Christelle Breton   +12 more
doaj   +1 more source