Results 101 to 110 of about 29,456 (288)

Enzymatic Studies of Glucuronide Formation in Impaired Liver I. Assay Methods For the Determination of Glucuronyl Transferase Activity and Uridine Diphosphate Glucuronic Acid Content of Liver Tissue Using 4-Methyl Umbelliferone as a Glucuronide Receptor; Its Application to Needle Liver Biopsy Tissues [PDF]

, 1962
An attempt was made to apply the method devised by ARIAS for the determination of liver glucuronyl transferase activity using 4-methyl umbelliferone as a glucuronide receptor to the small amounts of liver tissue obtained by needle biopsy.
Taketa, Kazuhisa
core   +1 more source

Modeling, virtual screening, and enzymatic docking of trehalose 6‐phosphate phosphatase and evaluation of the insecticidal effect of phthalimide, N‐(p‐tolylsulfonyl) on Aedes aegypti (Diptera: Culicidae)

Pest Management Science, Volume 81, Issue 8, Page 4777-4787, August 2025.
Schematic diagram of the experimental procedures used to perform the bioinformatic steps and insecticidal assays using trehalose 6‐phosphate phosphatase of Aedes aegypti and the molecule phthalimide, N‐(p‐tolylsulfonyl). Abstract BACKGROUND Aedes aegypti Linnaeus is a medically important vector because of its role in transmitting several arboviruses ...
Raquel Jemima Viana Lima, Fernando Berton Zanchi, Railton Marques de Souza Guimarães, Alexandre de Almeida e Silva   +3 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, Volume 15, Issue 7, Page 1176-1188, July 2025.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase

mBio
Multidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health.
Larissa Dirr, Sven Cleeves, Isabel Ramón Roth, Linghui Li, Timm Fiebig, Thomas Ve, Susanne Häussler, Armin Braun, Mark von Itzstein, Jana I. Führing   +9 more
doaj   +1 more source

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1710-1723, July 2025.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal, Erica Fratz‐Berilla, Casey Kohnhorst, David N. Powers, Shishir P. S. Chundawat   +4 more
wiley   +1 more source

Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]

, 2016
P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean, Kellam, Barrie, Kindon, Nicholas, Stocks, Michael   +3 more
core   +1 more source

Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus

Scientific Reports, 2022
Humans and Acanthamoeba polyphaga mimivirus share numerous homologous genes, including collagens and collagen-modifying enzymes. To explore this homology, we performed a genome-wide comparison between human and mimivirus using DELTA-BLAST (Domain ...
Wenhui Wu, Jeong Seon Kim, Aaron O. Bailey, William K. Russell, Stephen J. Richards, Tiantian Chen, Tingfei Chen, Zhenhang Chen, Bo Liang, Mitsuo Yamauchi, Houfu Guo   +10 more
doaj   +1 more source

Transcriptome and WGCNA Reveal the Key Genes of Arbuscular Mycorrhizal Fungi in Regulating Sugarcane Growth and Nutrient Absorption

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
AM fungal inoculation boosted sugarcane biomass and improved rhizosphere soil nutrient levels. RNA‐seq and WGCNA revealed gene modules linked to nutrient uptake and growth, differentiating above‐ and belowground responses. Hub genes (CESA9, ANR, CYCP4, LHA1, SUS4, RPS15AE, CNGC2) were identified as key regulators of sugarcane growth and nutrient ...
Lifang Mo, Ziqin Pang, Zhuowei Tan, Qiang Liu, Yixian Jia, Yijie Xiao, Zhaonian Yuan   +6 more
wiley   +1 more source

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

Control of Nucleotide Metabolism and Ribosomal Ribonucleic Acid Synthesis During Nitrogen Starvation of \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]

, 1972
Ribosomal ribonucleic acid (RNA) synthesis and ribonucleoside triphosphate metabolism were studied in cultures of Escherichia coli subjected to starvation for inorganic nitrogen.
Irr, Joseph D.
core   +1 more source