Results 191 to 200 of about 6,870,828 (229)
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Mutations affecting the activity of urokinase-type plasminogen activator
"Protein Engineering, Design and Selection", 1991Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid residues important for activity of scu-PA molecules.
L S, Davidow +4 more
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Ras Regulation of urokinase-type plasminogen activator
2001Publisher Summary This chapter describes the Ras regulation of urokinase-type plasminogen activator. Degradation of the extracellular matrix (ECM) is essential in many physiological and pathological processes, including involution of the prostate, cytotrophoblast implantation; wound healing, and tumor cell invasion, all of which require extensive ...
E, Lengyel +5 more
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Urokinase-type plasminogen activator and its inhibitor plasminogen activator inhibitor-1
Oncology Reports, 1997Tumor associated proteolysis is an essential mechanism in invasion and metastasis of cancer. The influence of the serine protease urokinase-like plasminogen activator (u-PA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1) on the clinical prognosis of squamous carcinoma of the head and neck region (HNSCC) was evaluated. U-PA and PAI-1 levels
B, Wollenberg +4 more
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Identification of a novel inhibitor of urokinase-type plasminogen activator
Molecular Cancer Therapeutics, 2007AbstractUrokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and pathologic processes. Strong clinical and experimental evidence has shown that elevated uPA expression is associated with cancer progression, metastasis, and shortened survival in patients.
Ming, Zhu +8 more
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Inhibitors of the Protease Domain of Urokinase-Type Plasminogen Activator
Current Pharmaceutical Design, 2002Human urokinase-type plasminogen activator (uPA or uPA) has been implicated in the regulation and control of basement membrane and interstitial protein degradation. Since Urokinase plays a role in tissue remodeling, it may be responsible, in part, for the disease progression of cancer.
T W, Rockway, V, Nienaber, V L, Giranda
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Modulators of the urokinase-type plasminogen activation system for cancer
Expert Opinion on Investigational Drugs, 2010The serine protease urokinase-type plasminogen activator (uPA) and its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type-1 (PAI-1) and type-2 (PAI-2), are involved in the control of extracellular matrix turnover and tumor growth.
Ralf, Hildenbrand +3 more
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Urokinase-type plasminogen activator in human eccrine sweat
British Journal of Dermatology, 1993The presence of urokinase-type plasminogen activator (uPA) in human eccrine sweat has not been reported previously. Clean sweat was obtained from the upper trunk and arms of subjects which had been painted with white petrolatum to minimize epidermal contamination. Sweat was concentrated x 50 by ultrafiltration, and its PA activity determined by the two-
T, Takemura, T, Hibino, K, Sato
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Bovine embryos produce a urokinase‐type plasminogen activator
Molecular Reproduction and Development, 1992AbstractThe type of plasminogen activator (PA) secreted by bovine embryos was identified. Day 12–14 embryos were collected from estrus‐synchronized, superovulated, and naturally mated crossbred beef cows. Embryos were left intact (E) or microdissected into component embryonic discs (ED) and trophoblastic vesicles (TV).
D A, Berg, A R, Menino
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New developments in the urokinase-type plasminogen activator system
Expert Opinion on Therapeutic Targets, 2001The urokinase-type plasminogen activator (uPA) system plays a central role in control of cell surface proteolysis and extracellular matrix degradation. Components of this system are upregulated in a wide variety of human cancers and high levels of these proteins predict more rapid relapse and shorter survival.
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