Results 181 to 190 of about 6,870,828 (229)

Circulating miR-10b, soluble urokinase-type plasminogen activator receptor, and plasminogen activator inhibitor-1 as predictors of non-small cell lung cancer progression and treatment response. [PDF]

Cancer Biomark
Setiawan L, Setiabudy R, Kresno SB, Sutandyo N, Syahruddin E, Jovianti F, Nadliroh S, Mubarika S, Setiabudy R, Siregar NC.   +9 more
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Association of Urokinase-type Plasminogen Activator with Asthma and Atopy

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Urokinase plasminogen activator (uPA) interacts with its receptor on inflammatory and migrating cells to regulate extracellular matrix degradation, cell adhesion, and inflammatory cell activation.
Catherine Laprise, Charleen Salesse
exaly   +5 more sources

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem, AKINCI, BARIŞ, Yesil, Sena, Tunali, Sunay, Tunc, Ulku Aybuke, Yuksel, Faize, Sevindik, Gokmen   +6 more
openaire   +4 more sources

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

Circulation, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Stefan Lorenzl, Elisabeth Deindl, Bernd Uhl   +2 more
exaly   +2 more sources

UVB Increases Urokinase-Type Plasminogen Activator Receptor (uPAR) Expression1 [PDF]

Journal of Investigative Dermatology, 1999
Keratinocytes synthesize and secrete urokinase-type plasminogen activator, which binds to its specific receptor on keratinocytes. When bound to urokinase-type plasminogen activator receptor, urokinase-type plasminogen activator proteolytically converts ...
Ernst Lengyel, Viktor Magdolen, Klaus Degitz   +2 more
exaly   +2 more sources

The murine urokinase-type plasminogen activator gene

Biochemistry, 1987
The murine urokinase-type plasminogen activator (uPA) gene has been isolated from a BALB/c liver DNA cosmid library and its nucleotide sequence established. The gene is organized into 11 exons comprising 34.7% of the 6710 base pair (bp) region spanning the interval between the presumed transcription initiation and polyadenylation sites.
S J, Degen, J L, Heckel, E, Reich, J L, Degen   +3 more
openaire   +2 more sources

Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou, Y, Hayashi, T, Itoh, W, Wang, J, Rui, H, Itoh   +5 more
openaire   +2 more sources

Urokinase-type plasminogen activator

The International Journal of Biochemistry & Cell Biology, 2007
Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
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Inhibitors of the Proteolytic Activity of Urokinase Type Plasminogen Activator

Current Pharmaceutical Design, 2003
Urokinase type plasminogen activator (uPA) activates plasminogen to plasmin and is often associated with diseases where tissue remodeling is essential (e.g. cancer, macular degeneration, atherosclerosis). We discuss some of the mechanisms of uPA action in diseases, and evidence that some of the early uPA inhibitors can modulate the progression of these
Todd W, Rockway, Vincent L, Giranda
openaire   +2 more sources

Modulation of lipoxidase activity by urokinase-type plasminogen activator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1994
Malignant cells show increased urokinase (UK) activity and decreased peroxidation of essential fatty acids (EFA). In order to explore this phenomenon the effect of UK on the lipoxidase activity was spectrophotometrically investigated. Decreased lipoxidase activity was obtained with increased UK concentrations (r = -1.000, p < 0.0001).
C H, van Aswegen, P J, du Toit, D J, du Plessis   +2 more
openaire   +2 more sources