Results 181 to 190 of about 7,182,421 (220)

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem, AKINCI, BARIŞ, Yesil, Sena, Tunali, Sunay, Tunc, Ulku Aybuke, Yuksel, Faize, Sevindik, Gokmen   +6 more
openaire   +3 more sources

Urokinase-type plasminogen activator and its inhibitor plasminogen activator inhibitor-1

Oncology Reports, 1997
Tumor associated proteolysis is an essential mechanism in invasion and metastasis of cancer. The influence of the serine protease urokinase-like plasminogen activator (u-PA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1) on the clinical prognosis of squamous carcinoma of the head and neck region (HNSCC) was evaluated. U-PA and PAI-1 levels
B, Wollenberg, N, Jan, R, Jund, S, Chaubal, M, Untch   +4 more
openaire   +2 more sources

Identification of a novel inhibitor of urokinase-type plasminogen activator

Molecular Cancer Therapeutics, 2007
AbstractUrokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and pathologic processes. Strong clinical and experimental evidence has shown that elevated uPA expression is associated with cancer progression, metastasis, and shortened survival in patients.
Ming, Zhu, Vijay M, Gokhale, Lajos, Szabo, Ruben M, Munoz, Hyounggee, Baek, Sridevi, Bashyam, Laurence H, Hurley, Daniel D, Von Hoff, Haiyong, Han   +8 more
openaire   +2 more sources

Inhibitors of the Protease Domain of Urokinase-Type Plasminogen Activator

Current Pharmaceutical Design, 2002
Human urokinase-type plasminogen activator (uPA or uPA) has been implicated in the regulation and control of basement membrane and interstitial protein degradation. Since Urokinase plays a role in tissue remodeling, it may be responsible, in part, for the disease progression of cancer.
T W, Rockway, V, Nienaber, V L, Giranda
openaire   +2 more sources

Modulators of the urokinase-type plasminogen activation system for cancer

Expert Opinion on Investigational Drugs, 2010
The serine protease urokinase-type plasminogen activator (uPA) and its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type-1 (PAI-1) and type-2 (PAI-2), are involved in the control of extracellular matrix turnover and tumor growth.
Ralf, Hildenbrand, Heike, Allgayer, Alexander, Marx, Philipp, Stroebel   +3 more
openaire   +2 more sources

Urokinase-type plasminogen activator in human eccrine sweat

British Journal of Dermatology, 1993
The presence of urokinase-type plasminogen activator (uPA) in human eccrine sweat has not been reported previously. Clean sweat was obtained from the upper trunk and arms of subjects which had been painted with white petrolatum to minimize epidermal contamination. Sweat was concentrated x 50 by ultrafiltration, and its PA activity determined by the two-
T, Takemura, T, Hibino, K, Sato
openaire   +2 more sources

Bovine embryos produce a urokinase‐type plasminogen activator

Molecular Reproduction and Development, 1992
AbstractThe type of plasminogen activator (PA) secreted by bovine embryos was identified. Day 12–14 embryos were collected from estrus‐synchronized, superovulated, and naturally mated crossbred beef cows. Embryos were left intact (E) or microdissected into component embryonic discs (ED) and trophoblastic vesicles (TV).
D A, Berg, A R, Menino
openaire   +2 more sources

New developments in the urokinase-type plasminogen activator system

Expert Opinion on Therapeutic Targets, 2001
The urokinase-type plasminogen activator (uPA) system plays a central role in control of cell surface proteolysis and extracellular matrix degradation. Components of this system are upregulated in a wide variety of human cancers and high levels of these proteins predict more rapid relapse and shorter survival.
openaire   +2 more sources

Urokinase-Type Plasminogen Activator

2008
openaire   +2 more sources

Urokinase-type plasminogen activator receptor

AfCS-Nature Molecule Pages, 2009
Nicolai Sidenius, Francesco Blasi
openaire   +1 more source