Results 171 to 180 of about 7,182,421 (220)

Amiloride Selectively Inhibits the Urokinase-Type Plasminogen Activator

FEBS Letters, 1987
The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 × 10−6 M.
Dominique Belin, J D Vassalli, D Belin
exaly   +5 more sources

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils via Mac-1, but Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

Circulation, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Johanna Pachmayr, Stefan Lorenzl, Elisabeth Deindl   +2 more
exaly   +2 more sources

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The murine urokinase-type plasminogen activator gene

Biochemistry, 1987
The murine urokinase-type plasminogen activator (uPA) gene has been isolated from a BALB/c liver DNA cosmid library and its nucleotide sequence established. The gene is organized into 11 exons comprising 34.7% of the 6710 base pair (bp) region spanning the interval between the presumed transcription initiation and polyadenylation sites.
S J, Degen, J L, Heckel, E, Reich, J L, Degen   +3 more
openaire   +2 more sources

Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou, Y, Hayashi, T, Itoh, W, Wang, J, Rui, H, Itoh   +5 more
openaire   +2 more sources

Urokinase-type plasminogen activator

The International Journal of Biochemistry & Cell Biology, 2007
Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
openaire   +2 more sources

Inhibitors of the Proteolytic Activity of Urokinase Type Plasminogen Activator

Current Pharmaceutical Design, 2003
Urokinase type plasminogen activator (uPA) activates plasminogen to plasmin and is often associated with diseases where tissue remodeling is essential (e.g. cancer, macular degeneration, atherosclerosis). We discuss some of the mechanisms of uPA action in diseases, and evidence that some of the early uPA inhibitors can modulate the progression of these
Todd W, Rockway, Vincent L, Giranda
openaire   +2 more sources

Modulation of lipoxidase activity by urokinase-type plasminogen activator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1994
Malignant cells show increased urokinase (UK) activity and decreased peroxidation of essential fatty acids (EFA). In order to explore this phenomenon the effect of UK on the lipoxidase activity was spectrophotometrically investigated. Decreased lipoxidase activity was obtained with increased UK concentrations (r = -1.000, p < 0.0001).
C H, van Aswegen, P J, du Toit, D J, du Plessis   +2 more
openaire   +2 more sources

Mutations affecting the activity of urokinase-type plasminogen activator

"Protein Engineering, Design and Selection", 1991
Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid residues important for activity of scu-PA molecules.
L S, Davidow, D R, Dumais, A P, Smyth, J, Greer, D T, Moir   +4 more
openaire   +2 more sources

Ras Regulation of urokinase-type plasminogen activator

2001
Publisher Summary This chapter describes the Ras regulation of urokinase-type plasminogen activator. Degradation of the extracellular matrix (ECM) is essential in many physiological and pathological processes, including involution of the prostate, cytotrophoblast implantation; wound healing, and tumor cell invasion, all of which require extensive ...
E, Lengyel, S, Ried, M M, Heiss, C, Jäger, M, Schmitt, H, Allgayer   +5 more
openaire   +2 more sources

Association of Urokinase-type Plasminogen Activator with Asthma and Atopy

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Urokinase plasminogen activator (uPA) interacts with its receptor on inflammatory and migrating cells to regulate extracellular matrix degradation, cell adhesion, and inflammatory cell activation.
Philippe, Bégin, Karine, Tremblay, Denise, Daley, Mathieu, Lemire, Sébastien, Claveau, Charleen, Salesse, Sabine, Kacel, Alexandre, Montpetit, Allan, Becker, Moira, Chan-Yeung, Anita L, Kozyrskyj, Thomas J, Hudson, Catherine, Laprise   +12 more
openaire   +4 more sources