Results 171 to 180 of about 23,635 (197)

Ras Regulation of urokinase-type plasminogen activator

2001
Publisher Summary This chapter describes the Ras regulation of urokinase-type plasminogen activator. Degradation of the extracellular matrix (ECM) is essential in many physiological and pathological processes, including involution of the prostate, cytotrophoblast implantation; wound healing, and tumor cell invasion, all of which require extensive ...
E, Lengyel, S, Ried, M M, Heiss, C, Jäger, M, Schmitt, H, Allgayer   +5 more
openaire   +2 more sources

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem, AKINCI, BARIŞ, Yesil, Sena, Tunali, Sunay, Tunc, Ulku Aybuke, Yuksel, Faize, Sevindik, Gokmen   +6 more
openaire   +3 more sources

Urokinase-type plasminogen activator and its inhibitor plasminogen activator inhibitor-1

Oncology Reports, 1997
Tumor associated proteolysis is an essential mechanism in invasion and metastasis of cancer. The influence of the serine protease urokinase-like plasminogen activator (u-PA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1) on the clinical prognosis of squamous carcinoma of the head and neck region (HNSCC) was evaluated. U-PA and PAI-1 levels
B, Wollenberg, N, Jan, R, Jund, S, Chaubal, M, Untch   +4 more
openaire   +2 more sources

Urokinase-type plasminogen activator in human eccrine sweat

British Journal of Dermatology, 1993
The presence of urokinase-type plasminogen activator (uPA) in human eccrine sweat has not been reported previously. Clean sweat was obtained from the upper trunk and arms of subjects which had been painted with white petrolatum to minimize epidermal contamination. Sweat was concentrated x 50 by ultrafiltration, and its PA activity determined by the two-
T, Takemura, T, Hibino, K, Sato
openaire   +2 more sources

Inhibitors of the Protease Domain of Urokinase-Type Plasminogen Activator

Current Pharmaceutical Design, 2002
Human urokinase-type plasminogen activator (uPA or uPA) has been implicated in the regulation and control of basement membrane and interstitial protein degradation. Since Urokinase plays a role in tissue remodeling, it may be responsible, in part, for the disease progression of cancer.
T W, Rockway, V, Nienaber, V L, Giranda
openaire   +2 more sources

Modulators of the urokinase-type plasminogen activation system for cancer

Expert Opinion on Investigational Drugs, 2010
The serine protease urokinase-type plasminogen activator (uPA) and its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type-1 (PAI-1) and type-2 (PAI-2), are involved in the control of extracellular matrix turnover and tumor growth.
Ralf, Hildenbrand, Heike, Allgayer, Alexander, Marx, Philipp, Stroebel   +3 more
openaire   +2 more sources

Identification of a novel inhibitor of urokinase-type plasminogen activator

Molecular Cancer Therapeutics, 2007
AbstractUrokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and pathologic processes. Strong clinical and experimental evidence has shown that elevated uPA expression is associated with cancer progression, metastasis, and shortened survival in patients.
Ming, Zhu, Vijay M, Gokhale, Lajos, Szabo, Ruben M, Munoz, Hyounggee, Baek, Sridevi, Bashyam, Laurence H, Hurley, Daniel D, Von Hoff, Haiyong, Han   +8 more
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Bovine embryos produce a urokinase‐type plasminogen activator

Molecular Reproduction and Development, 1992
AbstractThe type of plasminogen activator (PA) secreted by bovine embryos was identified. Day 12–14 embryos were collected from estrus‐synchronized, superovulated, and naturally mated crossbred beef cows. Embryos were left intact (E) or microdissected into component embryonic discs (ED) and trophoblastic vesicles (TV).
D A, Berg, A R, Menino
openaire   +2 more sources

Plasma Urokinase-Type Plasminogen Activator in Patients with Leukemias

Leukemia & Lymphoma, 1994
Plasma levels of urokinase-type plasminogen activator (u-PA) were measured with an enzyme-linked immunosorbent assay in patients with leukemias. As compared with healthy subjects (0.73 +/- SD 0.17 ng/ml), plasma u-PA antigen level was markedly elevated in patients with acute promyelocytic leukemia (APL) (1.76 +/- 0.89 ng/ml) at disease onset. Mean u-PA
K, Wada, H, Takahashi, M, Hanano, W, Tatewaki, H, Niwano, Y, Seki, A, Shibata   +6 more
openaire   +2 more sources

The urokinase type of plasminogen activator in cancer of digestive tracts

Thrombosis Research, 1988
The amounts of urokinase (UK) antigen and tissue plasminogen activator (t-PA) antigen were determined in plasma, urine and tissues of patients with cancer of digestive tracts. Urinary levels of UK, but not those of t-PA increased in patients with cancer, and generally decreased after the removal of cancer by operation. Urinary UK levels kept increasing
N, Nishino, K, Aoki, Y, Tokura, S, Sakaguchi, Y, Takada, A, Takada   +5 more
openaire   +2 more sources