Results 91 to 100 of about 175,762 (228)

The Plasma Proteome Mediates the Association Between Workplace Noise Exposure and Psychiatric Disorder Risk

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Workplace noise exposure was associated with adverse psychiatric outcomes and plasma proteomic alterations in the UK Biobank. Circulating proteins partially mediated associations with anxiety disorder and major depressive disorder (MDD), while workplace noise‐related protein risk scores provided proteomics‐based measures of individual susceptibility to
Xuan Zhao, Yan Fu, Dan‐Dan Zhang, Wei Xu, Hui‐Fu Wang, Wei Zhang, Jin‐Tai Yu, Lan Tan   +7 more
wiley   +1 more source

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

Scientific Reports, 2017
Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation.
Kamlesh K. Gupta, Deborah L. Donahue, Mayra J. Sandoval-Cooper, Francis J. Castellino, Victoria A. Ploplis   +4 more
doaj   +1 more source

Nuclear translocation of urokinase-type plasminogen activator

Blood, 2008
AbstractUrokinase-type plasminogen activator (uPA) participates in diverse (patho)physiological processes through intracellular signaling events that affect cell adhesion, migration, and proliferation, although the mechanisms by which these occur are only partially understood. Here we report that upon cell binding and internalization, single-chain uPA (
Victoria, Stepanova, Tatiana, Lebedeva, Alice, Kuo, Serge, Yarovoi, Sergei, Tkachuk, Sergei, Zaitsev, Khalil, Bdeir, Inna, Dumler, Michael S, Marks, Yelena, Parfyonova, Vsevolod A, Tkachuk, Abd Al-Roof, Higazi, Douglas B, Cines   +12 more
openaire   +3 more sources

A Single Smart Nanomaterial for Near‐Infrared‐Switchable Theranostics of Hemorrhage and Thrombosis via Photoacoustic Imaging

Small Science, Volume 6, Issue 11, November 2026.
A smart nanomaterial integrating Ag single atoms and nanoparticles on NiFe‐layered double hydroxides enables NIR‐switchable hemostasis and thrombolysis via photoelectric and photothermal effects. This platform allows real‐time photoacoustic imaging of active bleeding and exhibits rapid in vivo clearance, offering a dynamic theranostic strategy for ...
Yi Ye, Zhilu Sun, Daofu Wu, Jun’an Lai, Mingyue Yang, Zhiqiong Luo, Sha Cheng, Suwen Yang, Hong Zeng, Yinghui Li, Faguang Kuang, Baofei Sun, Wenxia Zhang, Xiaosheng Tang, Heng Luo, Guofeng Wu   +15 more
wiley   +1 more source

Regulation of skeletal muscle regeneration by macrophages and the urokinase-type plasminogen activator.

, 2007
Regulation of skeletal muscle regeneration by macrophages and the urokinase-type plasminogen ...
Scott C. Bryer (7949129)
core   +2 more sources

Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Medical Journal of Babylon
Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas, Zinah Abbass Ali, Alaa Sadiq Alaawad   +2 more
doaj   +1 more source

Akhirin Preserves Hemostatic Wound Repair Through Non-Hematopoietic Regulation of the Vascular Injury Microenvironment

Journal of Developmental Biology
Hemostasis and wound healing are highly coordinated processes that involve rapid clot formation followed by controlled remodeling of the injured tissue microenvironment.
Mohammad Badrul Anam, Mikiko Kudo, Terumasa Umemoto, Keisuke Yamashita, Rie Kawano, Kunimasa Ohta   +5 more
doaj   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, Volume 183, Issue 22, Page 6685-6703, November 2026.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report

BMC Ophthalmology, 2012
Background Corneal ulceration leading to perforation is associated with infectious and non-infectious destructive conditions in the cornea. The fibrinolytic (plasminogen/plasmin) system is considered to contribute to tissue remodeling in the wound ...
Sugioka Koji, Kodama Aya, Yoshida Koji, Okada Kiyotaka, Fukuda Masahiko, Shimomura Yoshikazu   +5 more
doaj   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source