Results 181 to 190 of about 175,762 (228)
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Urokinase-type plasminogen activator
The International Journal of Biochemistry & Cell Biology, 2007Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
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Urokinase Plasminogen Activator and Prognosis in Breast Cancer
Lancet, The, 1990Michael J Duffy +2 more
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Thrombosis Research, 1988
Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Glu-plasminogen (Glu-plg), Lys-plg and Val442-plg (mini-plg) were activated by urokinase (UK), streptokinase (SK) or tissue plasminogen activator (t-PA). Their activation rates were kinetically analyzed. UK activated Lys-plg with smaller Km and nearly identical Vmax as Glu-plg.
A, Takada, Y, Takada, Y, Sugawara
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Current Pharmaceutical Design, 2011
Urokinase (uPA) was originally identified in human urine for its ability to catalyse the transformation of plasminogen into its active form, plasmin which degrades fibrin and extracellular matrix components. Two major, functionally independent regions have been identified in the uPA molecule: a non-catalytic N-terminal region (residues 1-135) and a ...
Maria Vincenza, Carriero +1 more
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Urokinase (uPA) was originally identified in human urine for its ability to catalyse the transformation of plasminogen into its active form, plasmin which degrades fibrin and extracellular matrix components. Two major, functionally independent regions have been identified in the uPA molecule: a non-catalytic N-terminal region (residues 1-135) and a ...
Maria Vincenza, Carriero +1 more
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The Mechanisms of the Activation of Plasminogen by Streptokinase and Urokinase
1990Plasminogen activation to plasmin is due to enzymatic cleavage of a single peptide bond in the zymogen molecule. These enzymes are called plasminogen activators. There are three categories in plasminogen activators: streptokinase (SK), urokinase (UK) and tissue plasminogen activators (t-PA).
Y, Takada, A, Takada
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Activation of Porcine Plasminogen by Human Urokinase
Scandinavian Journal of Clinical and Laboratory Investigation, 1968Lauritsen, O. S. Activation of Porcine Plasminogen by Human Urokinase. Scand. J. clin. Lab. Invest. 22, 239-246, 1968.A plasminogen preparation from swine blood was activated by human urokinase. The preparation was solubilised and stabilised by an appropriate concentration of lysine.
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The Journal of Pharmacology and Experimental Therapeutics, 2007
Sympathetic neurons synthesize, transport, and release tissue-type plasminogen activators (t-PAs) and urinary-type plasminogen activators (u-PAs). We reported that t-PA enhances sympathetic neurotransmission and exacerbates reperfusion arrhythmias. We have now assessed the role of u-PA and plasminogen.
Ulrich, Schaefer +5 more
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Sympathetic neurons synthesize, transport, and release tissue-type plasminogen activators (t-PAs) and urinary-type plasminogen activators (u-PAs). We reported that t-PA enhances sympathetic neurotransmission and exacerbates reperfusion arrhythmias. We have now assessed the role of u-PA and plasminogen.
Ulrich, Schaefer +5 more
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Journal of Comparative Pathology, 2015
Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue.
Sh. Anwar, T. Yanai, H. Sakai
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Immunohistochemistry was used to assess the expression of urokinase plasminogen activator (uPA) and uPA receptor (uPAR) in 57 canine primary haemangiosarcomas (HSAs), 26 canine cutaneous haemangiomas (HAs) and in control sections of canine cutaneous granulation tissue.
Sh. Anwar, T. Yanai, H. Sakai
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Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou +5 more
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It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
L, Zhou +5 more
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Meningioma: Urokinase Plasminogen Activator
2012Meningiomas, which arise from the meninges, are by far the most frequently occurring intracranial primary tumors in adults. Histopathological and clinical variants of meningiomas offer new challenges in diagnosis, pathology and treatment modalities. Moreover, recurrence of the more aggressive tumors demand the development of novel, targeted therapeutic
Venkateswara Rao Gogineni +2 more
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