Results 91 to 100 of about 25,610 (245)

P2-099: Tumor Cell Expression of C4.4A, a Structural Homologue of the Urokinase Receptor, Correlates With Poor Prognosis in Non-Small Cell Lung Cancer [PDF]

, 2007
Birgit Guldhammer Skov, Line V. Hansen, Michael Ploug, Helle Pappot   +3 more
openalex   +1 more source

Astrocyte–vascular interplay in Alzheimer's disease pathology: Novel insights into stage‐specific biomarkers and therapeutic targets

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD). METHODS Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance ...
Zehu Sheng, Yuhao Chen, Ming Chen, Shuyu Liang, Jingyi Wang, Yingxi Chen, Rengui Li, Boyuan Xia, Kangjinyuan Gou, Siyuan Liu, Alzheimer's Disease Neuroimaging Initiative, Weihua Yu, Yang Lü   +12 more
wiley   +1 more source

Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes (Review)

Общая реаниматология, 2018
The multifunctional urokinase-type plasminogen activator system (uPA-system) includes serine proteinase — uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI-2).
Elena V. Kugaevskaya, Tatiana A. Gureeva, Olga S. Timoshenko, Nina I. Solovyeva   +3 more
doaj   +1 more source

Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts [PDF]

, 2014
L. Grove, Brian D. Southern, Tong Huan Jin, Kimberly E. White, Sailaja Paruchuri, Efrat Harel, Ying Wei, Shaik O. Rahaman, Candece L. Gladson, Qiang Ding, Charles S. Craik, Harold A. Chapman, Mitchell A. Olman   +12 more
openalex   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Urokinase Receptor uPAR Downregulation in Neuroblastoma Leads to Dormancy, Chemoresistance and Metastasis. [PDF]

Cancers (Basel), 2022
Shmakova AA, Klimovich PS, Rysenkova KD, Popov VS, Gorbunova AS, Karpukhina AA, Karagyaur MN, Rubina KA, Tkachuk VA, Semina EV.   +9 more
europepmc   +1 more source

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia, Erica Perri, Gustavo Baldassarre, Sandro Pignata, Chiara D'Alessio, Davide Limongello, Francesca Basso‐Valentina   +6 more
wiley   +1 more source

Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

Molecular Therapy: Nucleic Acids, 2019
MIR143 is pathologically downregulated and may function as a tumor suppressor in prostate cancer. Likewise, the urokinase plasminogen activator receptor (UPAR) is overexpressed in prostate carcinoma, representing a negative prognostic marker and putative
Sven Wach, Madeleine Brandl, Hannes Borchardt, Katrin Weigelt, Sabine Lukat, Elke Nolte, Omar Al-Janabi, Martin Hart, Friedrich Grässer, Johannes Giedl, Rudolf Jung, Robert Stöhr, Arndt Hartmann, Verena Lieb, Sabrina Höbel, Anna Peters, Claudia Stäubert, Bernd Wullich, Helge Taubert, Achim Aigner   +19 more
doaj   +1 more source

The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities. [PDF]

Cancers (Basel), 2021
Metrangolo V, Ploug M, Engelholm LH.
europepmc   +1 more source

Exploiting Lactic Acid Bacteria for Regulating Autophagy to Improve Health in Foods and Supplements: A Recent Update

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Lactic acid bacteria (LAB) are frequently used as health supplements. They enhance digestion, regulate immunity, improve gut microbiota, and prevent and manage diseases. Autophagy has a crucial role in the prevention and treatment of tumors, cardiovascular diseases, and pathogenic infections.
Yang Chen, Fangyi Chen, Mengchen Li, Junfeng Xiao, Yang Mu, Chao Wang, Lusha Xia, Mingye Peng, Mengzhou Zhou   +8 more
wiley   +1 more source