Results 121 to 130 of about 2,335,681 (277)

Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective A cardiovascular safety issue has been associated with JAK inhibitors (JAKi). This study compares the effects of distinct approved JAKi on endothelial cell (EC) dysfunction and apoptosis during inflammation. Methods Massive inflammation was induced in human vascular ECs by tumor necrosis factor (TNF) with interleukin‐17A (IL‐17A) treated or ...
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

Probing Cholesterol-Dependence of Integrin-Urokinase Receptor Complex Formation using Confocal Dual-Color Fluorescence Intensity Analysis [PDF]

, 2017
Yifan Ge, Jiayun Gao, Rainer Jordan, Christoph Naumann   +3 more
openalex   +1 more source

Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Annals of Neurology, Volume 98, Issue 6, Page 1299-1314, December 2025.
Objective The efficacy and safety of intra‐arterial thrombolysis (IAT) as an adjunct to endovascular thrombectomy (EVT) in large vessel occlusion strokes (LVOS) remain uncertain, with recent randomized controlled trials (RCTs) yielding conflicting results.
Mohamed F. Doheim, Mahmoud H. Mohammaden, Ammar Jumah, Qingwu Yang, Wenjie Zi, Yangmei Chen, Yamei Tang, Yajie Liu, Xiaochuan Huo, Liping Liu, Bernard Yan, Zhongrong Miao, Wei Hu, Chunrong Tao, Xinfeng Liu, Liqun Jiao, Xuesong Bai, Wenhuo Chen, Diogo C. Haussen, Thanh Nguyen, Raul G. Nogueira   +20 more
wiley   +1 more source

Soluble Urokinase Receptor and Mortality in Kidney Transplant Recipients. [PDF]

Transpl Int, 2021
Morath C, Hayek SS, Döhler B, Nusshag C, Sommerer C, Zeier M, Reiser J, Süsal C.   +7 more
europepmc   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Screening, Purification, and Characterization of Protease Inhibitors From Different Legume Seeds With Cytotoxic and Antimicrobial Effects

Legume Science, Volume 7, Issue 4, December 2025.
ABSTRACT This study reports the purification and characterization of protease inhibitors (PIs) from three Egyptian legumes: soybean (Glycine max), cowpea (Vigna unguiculata), and chickpea (Cicer arietinum). Their antimicrobial and cytotoxic activities were also assessed.
Mona M. Ibrahim, Andrea Cavallero, Eman R. Zaki, Mohamed R. Rady, Cristiana Sbrana, Morena Gabriele   +5 more
wiley   +1 more source

A Global Transcriptomic Analysis Reveals Body Weight‐Specific Molecular Responses to Chronic Orange Juice Consumption in Healthy Individuals

Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.
This study aimed to investigate the molecular pathways involved in the health benefits of chronic orange juice (OJ) consumption through global transcriptomic approach in peripheral blood mononuclear cells (PBMCs). Healthy volunteers consumed 500 mL of OJ daily for 60 days.
Layanne Nascimento Fraga, Dragan Milenkovic, Isabella de Araújo Esteves Duarte, Saivageethi Nuthikattu, Camille Perella Coutinho, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto   +6 more
wiley   +1 more source

Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
In this prospective study of UK Biobank participants, type 2 diabetes (T2DM) was associated with poorer cognitive performance and a 2.13‐fold higher risk of incident dementia over 15 years. Four‐way decomposition models including 2923 proteomic, and KEGG pathway analyses, were used to implicate biological pathways in the association between T2DM and ...
Sofia E. Perfetto, Myuri Ruthirakuhan, Si Won Ryoo, Yuen Yan Wong, Lisa Y. Xiong, Natasha Z. Anita, Nathanael A. Caveney, Landon J. Edgar, John W. Newman, Hugo Cogo‐Moreira, Walter Swardfager   +10 more
wiley   +1 more source

BIOCHEMICAL MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS IN ATHEROSCLEROSIS AND THE GENES RESPONSIBLE FOR THEIR REGULATION

Атеросклероз, 2017
The review systematized modern concepts of markers of endothelial dysfunction and disorders of hemostasis (asymmetric dimethylarginine, endothelin 1, adhesive ICAM and VCAM molecules, apolipoproteins, antithrombin III, receptor of urokinase plasminogen ...
E. V. Stryukova, Yu. I. Ragino, V. N. Maksimov   +2 more
doaj  

Soluble Urokinase Receptor as a Promising Marker for Early Prediction of Outcome in COVID-19 Hospitalized Patients. [PDF]

J Clin Med, 2021
Napolitano F, Di Spigna G, Vargas M, Iacovazzo C, Pinchera B, Spalletti Cernia D, Ricciardone M, Covelli B, Servillo G, Gentile I, Postiglione L, Montuori N.   +11 more
europepmc   +1 more source