Results 51 to 60 of about 2,335,681 (277)

The role of soluble urokinase plasminogen activator receptor (suPAR) in patients with cancer: a review of the current literature [PDF]

Medicinski Glasnik, 2022
Aim Several biomarkers are currently used as diagnostic and prognostic tools in patients with cancer. Soluble urokinase plasminogen activator receptor (suPAR) is elevated in acute and chronic inflammatory procedures and several observational studies ...
Themistoklis Paraskevas, Francesk Mulita, Christos Michailides, Georgios-Ioannis Verras, Elias Liolis, Eleousa Oikonomou, Ioannis Perdikaris, Konstantinos Bouchagier, Ioannis Panagiotopoulos, Dimitrios-Ioannis Kasartzian, Dimitrios Filis, Levan Tchabashvili, Despoina Spyropoulou, Dimitrios Velissaris   +13 more
doaj   +1 more source

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]

PLoS Pathogens, 2009
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll   +15 more
doaj   +1 more source

Soluble urokinase plasminogen activation receptor - An emerging new biomarker of cardiovascular disease and critical illness

Annals of Cardiac Anaesthesia, 2016
Soluble urokinase plasminogen activation receptor (suPAR) is an emerging new biomarker, which has been shown to not only correlate with traditional biomarkers but also outperform CRP at prognosticating CVD.
Nicole B Cyrille, Pedro A Villablanca, Harish Ramakrishna   +2 more
doaj   +1 more source

Prognostic effects of SuPAR and Neopterin Levels on Patients with Lung Cancer

Pteridines, 2020
Background: Two unique biomarkers, soluble form of the urokinase-type plasminogen activator receptor (suPAR) and neopterin, play a crucial role in inflammatory processes.
Yalcin Selim, Demir Mehmet Emin, Ozturk Reyhan, Kılınç Aytün Şadan, Suer Hatice, Karahan Irfan   +5 more
doaj   +1 more source

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms

Cells, 2020
The urokinase (uPA) receptor (uPAR) plays a key role in cell migration. We previously showed that uPAR-negative HEK-293 cells efficiently migrate toward serum but, after uPAR ectopic expression, migrate only in a uPAR-dependent manner. In fact, migration
Anna Gorrasi, Anna Maria Petrone, Anna Li Santi, Mariaevelina Alfieri, Nunzia Montuori, Pia Ragno   +5 more
doaj   +1 more source

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

Communications Biology, 2021
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans.
Joseph Dowsett, Egil Ferkingstad, Line Jee Hartmann Rasmussen, Lise Wegner Thørner, Magnús K. Magnússon, Karen Sugden, Gudmar Thorleifsson, Mike Frigge, Kristoffer Sølvsten Burgdorf, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Thomas Folkmann Hansen, Karina Banasik, Søren Brunak, DBDS Genomic Consortium, Vinicius Tragante, Sigrun Helga Lund, Lilja Stefansdottir, Bjarni Gunnarson, Richie Poulton, Louise Arseneault, Avshalom Caspi, Terrie E. Moffitt, Daníel Gudbjartsson, Jesper Eugen-Olsen, Hreinn Stefánsson, Kári Stefánsson, Henrik Ullum   +29 more
doaj   +1 more source

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Frontiers in Oncology, 2018
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes.
Niaz Mahmood, C. Mihalcioiu, S. Rabbani
semanticscholar   +1 more source

The urokinase/urokinase receptor system in mast cells: effects of its functional interaction with fmlf receptors

Translational medicine @ UniSa, 2016
Mast cell and basophils express the high affinity receptor for IgE (FcRI) and are primary effector cells of allergic disorders. The urokinase (uPA)-mediated plasminogen activation system is involved in physiological and pathological events based on cell migration and tissue remodelling, such as inflammation, wound healing, angiogenesis and metastasis.
ROSSI, FRANCESCA WANDA, PREVETE, Nella, Rivellese, Felice, Napolitano, Filomena, MONTUORI, NUNZIA, POSTIGLIONE, LOREDANA, Selleri, Carmine, DE PAULIS, AMATO   +7 more
openaire   +5 more sources

Augmented Urokinase Receptor Expression in Atheroma [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
Abstract Smooth muscle cell proliferation and migration into neointima are hallmarks of atherogenesis. However, mechanisms responsible have not yet been fully elucidated. One potential mediator of both smooth muscle cell proliferation and migration is activation of plasminogen by activators bound to receptors on cells within ...
H, Noda-Heiny, A, Daugherty, B E, Sobel
openaire   +2 more sources

Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study

Cardio-Oncology
Background Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established ...
Jian Chu, Lillian Tung, Issam Atallah, Changli Wei, Melody Cobleigh, Ruta Rao, Steven B. Feinstein, Lydia Usha, Kathrin Banach, Jochen Reiser, Tochukwu M. Okwuosa   +10 more
doaj   +1 more source