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Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease [PDF]

Nutrients, 2021
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Eugene Hone, Gilles J Guillemin, Ralph Martins   +2 more
exaly   +4 more sources

In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A

Applied Microbiology and Biotechnology
Abstract The metabolite urolithin A, a metabolite of the dietary polyphenol ellagic acid (EA), has significant health benefits for humans. However, studies on the gut microbiota involved in ellagic acid metabolism are limited.
Yaowei Fang, Xiaoyue Hou
exaly   +3 more sources

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The Synthesis of Urolithins and their Derivatives and the Modes of Antitumor Action

Mini-Reviews in Medicinal Chemistry, 2023
Abstract: Urolithins are microbial metabolites derived from berries and pomegranate fruits, which display anti-inflammatory, anti-oxidative, and anti-aging activities. There are eight natural urolithins (urolithin A-E, M5, M6 and M7), which have been isolated by now.
Lei Yao, Xiangrong Xu, Zhuanhong Liu
openaire   +2 more sources

Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial

Nutrients
Background: In healthy adults, probiotic supplementation alone does not increase Urolithin A (UroA) and rarely increases butyrate, both microbiome-derived metabolites that influence key biological functions involved in regulating gastrointestinal ...
Brooke A Napier, J. Allegretti, P. Feuerstadt, Colleen R. Kelly, Nicholas W. Van Hise, R. Jäger, Z. Kassam, Gregor Reid   +7 more
semanticscholar   +1 more source

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
MENA PARRENO, Pedro Miguel, DALL'ASTA, Margherita, CALANI, Luca, BRIGHENTI, Furio, DEL RIO, Daniele   +4 more
openaire   +5 more sources

Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury.

International Immunopharmacology
Spinal cord injury (SCI) is a potentially fatal condition that often results in loss of motor and sensory functions, thereby significantly burdening global health initiatives. Urolithin A (UA), an intestinal microbial metabolite of ellagic acid, is known
Kongbin Chen, Jiahao Ying, Jiangwei Zhu, Liang Chen, Rongjie Liu, Mengqi Jing, Yuchao Wang, Kailiang Zhou, Long Wu, Chenyu Wu, Jian Xiao, Wen-Fei Ni   +11 more
semanticscholar   +1 more source

Urolithin a attenuates rheumatoid arthritis by inhibiting inflammation and pyroptosis in fibroblasts via the AMPK/ NF-κB signaling pathway.

International Immunopharmacology
Urolithin A (UA), a metabolite of natural polyphenols produced by the gut microbiota, alleviates the symptoms of rheumatoid arthritis (RA) by inhibiting the inflammatory response.
Hao Chen, Zhen Zhang, Congcong Lu, Yi Ding, Zhengao Huang, Mao-Qiang Li, Liu-Long Zhu   +6 more
semanticscholar   +1 more source

Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su   +3 more
openaire   +2 more sources

Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation.

ACS Chemical Neuroscience
Neuroinflammation is a key factor in age-related cognitive decline and memory impairment. UAS03, a potent synthetic analogue of Urolithin-A, has demonstrated anti-inflammatory and antioxidant properties.
Dipan Maity, Vikrant Rahi, Sandya Tambi Dorai, Sandeep Chandrashekharappa, Ravinder K. Kaundal   +4 more
semanticscholar   +1 more source

Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages

Journal of Advanced Research
Graphical ...
Lin Fang
exaly   +2 more sources