Results 191 to 200 of about 5,657 (242)

Urolithin-A supplementation alleviates sepsis-induced acute lung injury by reducing mitochondrial dysfunction and modulating macrophage polarization.

Mitochondrion (Amsterdam. Print)
Sepsis is a severe and life-threatening condition marked by excessive inflammation, mitochondrial dysfunction, and epithelial barrier disruption, often leading to Acute Lung Injury (ALI). Mitophagy, a cellular mechanism that removes damaged mitochondria,
Mohd Mohsin, Almaz Zaki, Gulnaz Tabassum, Salman Khan, Shakir Ali, Tanveer Ahmad, M. Syed   +6 more
semanticscholar   +1 more source

Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.

International Immunopharmacology
The management of cognitive impairments in schizophrenia presents a considerable challenge, with a strong association between neuroinflammation and its progression.
Zhengyuan Huang, Guanghui Chen, Zhongyu Ren, Ling Xiao, Ziyue Chen, Yinping Xie, Gaohua Wang, Ben-Hong Zhou   +7 more
semanticscholar   +1 more source

Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy.

International Immunopharmacology
BACKGROUND Radiation pneumonitis (RP) is a common and severe complication of radiotherapy, whose pathogenesis involves complex inflammatory responses and cellular damage. Despite its clinical significance, effective treatments remain limited.
Anqi Zhang, Shi-Lan Luo, Peng Li, Lu Meng, Litang Huang, Hongxia Cheng, Chenhui Zhao, Hongbin Tu, Xiao-Mei Gong   +8 more
semanticscholar   +1 more source

Urolithin a improves Parkinson's disease-associated cognitive impairment through modulation of neuroinflammation and neuroplasticity.

Experimental Neurology
Cognitive impairment is one of the most common disabling non-motor manifestations of Parkinson's disease (PD), an age-onset condition for which there are no effective therapies available to date.
Ning Xu, Chenchen Du, Yuan Yu, Yile Li, Shixuan Gao, Shu-Yan Yu, Baozhu Sun, Haiyan Lou   +7 more
semanticscholar   +1 more source

Urolithin A protects mice against osteoarthritis by inhibiting chondrocyte ferroptosis through activating AMPK/mTOR/HIF-1α signaling pathway.

Journal of Nutritional Biochemistry
Urolithin A (UA) is a metabolite of natural polyphenols tannic acid and tannic acid produced by the gut microbiota that has multiple pharmacological effects. However, the effects of UA on osteoarthritis (OA) have not been reported.
Xu-Kai Wang, Qinli Xu, Jinzhen Huang, Yating Gao, Fangliang Zheng, Guangya Liu   +5 more
semanticscholar   +1 more source

Urolithin A's Role in Alleviating Severe Acute Pancreatitis via Endoplasmic Reticulum-Mitochondrial Calcium Channel Modulation.

ACS Nano
Severe acute pancreatitis (SAP), characterized by pancreatic acinar cell death, currently lacks effective targeted therapies. Ellagic acid (EA), rich in pomegranate, shows promising anti-inflammatory and antioxidant effects in SAP treatment. However, the
Hong-Xin Kang, Qian Hu, Yue Yang, Gaigai Huang, Juan Li, Xian-Lin Zhao, L.-V. Zhu, Hang Su, Wenfu Tang, Meihua Wan   +9 more
semanticscholar   +1 more source

Urolithin D: A Promising Metabolite of Ellagitannin in Combatting Oxidative Stress.

Chemico-Biological Interactions
The objective of this research is to examine the function of urolithin D (UroD, 3,4,8,9-tetrahydroxy-6H-benzo[c]chromen-6-one), a metabolite obtained from ellagitannins, in the mitigation of oxidative stress.
Žiko B. Milanović
semanticscholar   +1 more source

Research progress of ellagitannin intestinal metabolite urolithins

China Journal of Chinese Materia Medica, 2016
Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou, Zhen-Peng, Qiu, Hui-Lan, Yi, Ding-Shan, Zhou, Jing, Wang, Yue, Wu   +5 more
openaire   +2 more sources

Urolithin A enhances diabetic wound healing: Insights from parkin-mediated mitophagy in endothelial progenitor cells.

International Immunopharmacology
Diabetes is often associated with delayed wound healing, where endothelial progenitor cells (EPCs) play a key role in maintaining vascular integrity and promoting angiogenesis.
Xia Fang, Zhenxuan Shao, Hongfeng Ding, Haoxiang Xu, Zhuo-Long Tu, Hui Wang, Dawei Li, Cheng Huang, Chang Jiang   +8 more
semanticscholar   +1 more source

Bioactive release and modulation of urolithin metabotype A phenotype gut microbiota during in vitro digestion and fermentation of ellagic acid-rich fruit polyphenols.

Food & Function
Ellagic acid-rich fruits (EARFs) are valued for their bioactive compounds, yet their gastrointestinal biotransformation remains insufficiently understood.
Zhike Xie, Feng Chen, Yawen Xiao, Jiaxin You, Xiaojun Zhou, Pei Li, Quancheng Zhou, Zheng Ruan   +7 more
semanticscholar   +1 more source