Results 201 to 210 of about 5,657 (242)
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Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
bioRxivSenescent cells are known to contribute to aging and age-related diseases. One key way they influence aging is by secreting senescence-associated secretory phenotype (SASP) factors along with several damage-associated molecular pattern (DAMP) molecules ...
Anna Barkovskaya +7 more
semanticscholar +1 more source
Neurotoxicology
α-synuclein aggregation is a key hallmark of Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). We examined the multi-targeting effects of urolithin (UA, UB, UC, UD, UE, UM5, and UM6) against α-synuclein ...
Ankita Devi +5 more
semanticscholar +1 more source
α-synuclein aggregation is a key hallmark of Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). We examined the multi-targeting effects of urolithin (UA, UB, UC, UD, UE, UM5, and UM6) against α-synuclein ...
Ankita Devi +5 more
semanticscholar +1 more source
Urolithin A Exhibits Antidepressant-like Effects by Modulating the AMPK/CREB/BDNF Pathway
NutrientsBackground/Objectives: Urolithin A (UA), a gut-derived metabolite of ellagitannins or ellagic acid, has recently gained attention for its potential benefits to brain health. The present research aimed to assess the antidepressant-like properties of UA in
Yaqian Di +7 more
semanticscholar +1 more source
Phytomedicine
BACKGROUND Osteoarthritis (OA) is a prevalent chronic disease characterized by articular cartilage degeneration. The lack of safe and effective therapies has made OA a leading global cause of disability, severely impacting patient quality of life ...
Yanlin Li +13 more
semanticscholar +1 more source
BACKGROUND Osteoarthritis (OA) is a prevalent chronic disease characterized by articular cartilage degeneration. The lack of safe and effective therapies has made OA a leading global cause of disability, severely impacting patient quality of life ...
Yanlin Li +13 more
semanticscholar +1 more source
Journal of Agricultural and Food Chemistry
This study aimed to identify the lactonase gene in Limosilactobacillus fermentum FUA033 that facilitates the conversion of ellagic acid into urolithin A. Lactonase gene candidates were identified genome analysis. A series of overexpression, knockout, and
Ze Wang +9 more
semanticscholar +1 more source
This study aimed to identify the lactonase gene in Limosilactobacillus fermentum FUA033 that facilitates the conversion of ellagic acid into urolithin A. Lactonase gene candidates were identified genome analysis. A series of overexpression, knockout, and
Ze Wang +9 more
semanticscholar +1 more source
Synthesis of urolithin derivatives and their anti-inflammatory activity
Biochemical and Biophysical Research CommunicationsTwo series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li +5 more
openaire +2 more sources
Food & Function
Ellagic acid (EA) exhibits protective effects on non-alcoholic fatty liver disease (NAFLD). However, the ability to produce urolithins and the health benefits associated with EA consumption differ considerably among individuals.
Fengping Li +6 more
semanticscholar +1 more source
Ellagic acid (EA) exhibits protective effects on non-alcoholic fatty liver disease (NAFLD). However, the ability to produce urolithins and the health benefits associated with EA consumption differ considerably among individuals.
Fengping Li +6 more
semanticscholar +1 more source
Targeting aging with urolithin A in humans
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10–1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, Ajla Hodzic +6 more
openaire +1 more source
Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed
Journal of Agricultural and Food Chemistry, 2023David Beltran Riquelme +2 more
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