Results 191 to 200 of about 4,757 (208)

Urolithin A attenuates arsenic-induced gut barrier dysfunction

Archives of Toxicology, 2022
Environmental chemicals such as inorganic arsenic (iAs) significantly contribute to redox toxicity in the human body by enhancing oxidative stress. Imbalanced oxidative stress rapidly interferes with gut homeostasis and affects variety of cellular processes such as proliferation, apoptosis, and maintenance of intestinal barrier integrity.
Sweta Ghosh, Mayukh Banerjee, Bodduluri Haribabu, Venkatakrishna Rao Jala   +3 more
openaire   +2 more sources

Research progress of ellagitannin intestinal metabolite urolithins

China Journal of Chinese Materia Medica, 2016
Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins.
Ben-Hong, Zhou, Zhen-Peng, Qiu, Hui-Lan, Yi, Ding-Shan, Zhou, Jing, Wang, Yue, Wu   +5 more
openaire   +2 more sources

Gastrointestinal stability of urolithins: an in vitro approach

European Journal of Nutrition, 2015
Urolithins are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative ...
Mena P., Dall'Asta M., Calani L., Brighenti F., Del Rio D.   +4 more
openaire   +4 more sources

Antimelanogenic Effect of Urolithin A and Urolithin B, the Colonic Metabolites of Ellagic Acid, in B16 Melanoma Cells

Journal of Agricultural and Food Chemistry, 2017
Antimelanogenic agents from natural sources have been widely investigated. Urolithin A (UA) and B (UB), the main gut microflora metabolites of dietary ellagic acid derivatives, have various bioactivities such as anti-inflammatory and antiaging effects.
Shang-Ta Wang, Wei-Chia Chang, Chen Hsu, Nan-Wei Su   +3 more
openaire   +2 more sources

Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo

Journal of Agricultural and Food Chemistry, 2022
Urolithin A (UA) is a metabolite produced in the gut following the consumption of ellagic acid (EA) rich foods. EA has shown anti-inflammatory, antioxidant, and anticancer properties. Because EA is poorly absorbed in the gastrointestinal tract, urolithins are considered to play a major role in bioactivity. Helicobacter pylori (H.
Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li, Tian-yi Li, Qian Chen, Jian Zhao   +9 more
openaire   +2 more sources

The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

Food and Chemical Toxicology, 2020
The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers. Urolithins (Uros) are ellagitannins and ellagic acid-derived gut microbiota metabolites that reach high concentrations in the human colon.
Juan Antonio, Giménez-Bastida, María Ángeles, Ávila-Gálvez, Juan Carlos, Espín, Antonio, González-Sarrías   +3 more
openaire   +2 more sources

Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

Journal of Agricultural and Food Chemistry, 2010
Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC(50) values ranging from 56.7 microM for urolithin A to 74.8 microM for urolithin C.
Sashi G, Kasimsetty, Dobroslawa, Bialonska, Muntha K, Reddy, Guoyi, Ma, Shabana I, Khan, Daneel, Ferreira   +5 more
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Urolithin A Nanoparticle Therapy for Cisplatin-Induced Acute Kidney Injury

Nephron, 2022
Cisplatin continues to be one of the frontline cytotoxic drugs. However, cisplatin-induced acute kidney injury (AKI) remains a major unmet medical need without any approved pharmacological interventions. The involvement of reactive oxygen species generation and activation of inflammatory and apoptotic pathways in the pathogenesis of cisplatin-induced ...
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Synthesis of urolithin derivatives and their anti-inflammatory activity

Biochemical and Biophysical Research Communications
Two series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li, Zhengzheng Zhang, Guangsen Xu, Zhiying Li, Chunhua Lu, Yuemao Shen   +5 more
openaire   +2 more sources

Appeal of Urolithins from Synthesis to Biological Activities

Journal of Agricultural and Food Chemistry
Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
openaire   +2 more sources