Results 41 to 50 of about 3,771 (207)

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D

Biochemistry and Biophysics Reports, 2020
Mediated by the nuclear vitamin D receptor (VDR), the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D), is known to regulate expression of genes impacting calcium and phosphorus metabolism, the immune system, and behavior ...
Sarah Livingston, Sanchita Mallick, Daniel A. Lucas, Marya S. Sabir, Zhela L. Sabir, Hespera Purdin, Sree Nidamanuri, Carol A. Haussler, Mark R. Haussler, Peter W. Jurutka   +9 more
doaj   +1 more source

Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives

Frontiers in Nutrition, 2022
Selective estrogen receptor modulators (SERMs) have been used in hormone related disorders, and their role in clinical medicine is evolving. Tamoxifen and raloxifen are the most commonly used synthetic SERMs, and their long-term use are known to create ...
Ravindran Vini, Juberiya M. Azeez, Viji Remadevi, T. R. Susmi, R. S. Ayswarya, Anjana Sasikumar Sujatha, Parvathy Muraleedharan, Lakshmi Mohan Lathika, Sreeja Sreeharshan   +8 more
doaj   +1 more source

In Silico and In Vitro Study of Antioxidant Potential of Urolithins

Antioxidants, 2023
In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA), also known as urolithins (UROs). In order to evaluate their ability to counter the effect of oxidative
Emanuela Marchese, Valentina Orlandi, Federica Turrini, Isabella Romeo, Raffaella Boggia, Stefano Alcaro, Giosuè Costa   +6 more
openaire   +3 more sources

The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
The investigation of biological activities of natural products, particularly considering the secondary metabolites, continuously receives attention.
Hayrettin Ozan GÜLCAN, Mehmet İLKTAÇ, Bahareh NOSHADİ, Karar SHUKUR, Mustafa GAZİ   +4 more
doaj   +1 more source

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

Molecules, 2016
The consumption of foodstuffs yielding circulating compounds able to maintain endothelial function by improving nitric oxide (NO) bioavailability can be considered as an effective strategy for cardiovascular disease prevention.
Valentina Spigoni, Pedro Mena, Monia Cito, Federica Fantuzzi, Riccardo C. Bonadonna, Furio Brighenti, Alessandra Dei Cas, Daniele Del Rio   +7 more
doaj   +1 more source

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Frontiers in Endocrinology, 2022
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease ...
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Cláudia N. dos Santos, Regina Menezes, Regina Menezes, Regina Menezes   +15 more
doaj   +1 more source

Urolithins: A Prospective Alternative against Brain Aging

Nutrients, 2023
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei, Lu, Qiu, Wang, Ke, Wang, Yousheng   +3 more
openaire   +2 more sources

Urolithin B, a newly identified regulator of skeletal muscle mass. [PDF]

, 2017
The control of muscle size is an essential feature of health. Indeed, skeletal muscle atrophy leads to reduced strength, poor quality of life, and metabolic disturbances.
Pierre, Nicolas, Nicolas Pierre, Ferreira, Daneel, Damien Naslain, Rodriguez, Julie, Daneel Ferreira, Francaux, Marc, Françoise Bontemps, Julie Rodriguez, Bontemps, Françoise, Marc Francaux, Louise Deldicque, Priem, Fabian, Deldicque, Louise, Naslain, Damien, Fabian Priem   +15 more
core   +1 more source

Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10^−/− Mice

Pathogens, 2020
Human campylobacteriosis represents an infectious enteritis syndrome caused by Campylobacter species, mostly Campylobacter jejuni. Given that C. jejuni infections are rising worldwide and antibiotic treatment is usually not indicated, novel treatment ...
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat   +3 more
doaj   +1 more source

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Food Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso   +5 more
doaj   +1 more source