Results 211 to 220 of about 21,131,763 (241)

Urolithin A Exhibits Antidepressant-like Effects by Modulating the AMPK/CREB/BDNF Pathway

Nutrients
Background/Objectives: Urolithin A (UA), a gut-derived metabolite of ellagitannins or ellagic acid, has recently gained attention for its potential benefits to brain health. The present research aimed to assess the antidepressant-like properties of UA in
Yaqian Di, Rui Xue, Xia Li, Zi-Jia Jin, Hanying Li, Lanrui Wu, Youzhi Zhang, Lei An   +7 more
semanticscholar   +1 more source

The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

Current Cancer Drug Targets, 2022
Background: Urolithin A is the metabolite of natural polyphenol ellagic acid and ellagitannins generated by gut microbiota. Urolithin A is better absorbed in the gastrointestinal tract than its parent substances. Thus, the variable effects of ellagitannin-reach food (like pomegranate fruit, walnuts, tea, and others) on people's health might be linked ...
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The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells

Nutrition and Metabolism
Polyphenolic plant extracts have demonstrated anti-inflammatory and anti-catabolic effects in vitro, however their meaningful translation into humans remains elusive.
A. Wilhelmsen, Leonidas G. Karagounis, Andrew J Bennett, Davide D’Amico, A. Fouassier, Simon W. Jones, K. Tsintzas   +6 more
semanticscholar   +1 more source

Function Identification of a Lactonase Gene lac1563 Involved in Producing Urolithin A of Limosilactobacillus fermentum FUA033.

Journal of Agricultural and Food Chemistry
This study aimed to identify the lactonase gene in Limosilactobacillus fermentum FUA033 that facilitates the conversion of ellagic acid into urolithin A. Lactonase gene candidates were identified genome analysis. A series of overexpression, knockout, and
Ze Wang, Xiaoli Liu, Shu Liu, Wenmei Zhou, Tao Chen, Song Gao, Hao Wu, Wenjun Zhang, Rui Tang, Yaowei Fang   +9 more
semanticscholar   +1 more source

Urolithin A Protects Porcine Oocytes from Artificially Induced Oxidative Stress Damage to Enhance Oocyte Maturation and Subsequent Embryo Development

International Journal of Molecular Sciences
Both the livestock and biomedical fields require a large supply of high-quality mature oocytes. However, the in vitro maturation (IVM) process often leads to an accumulation of reactive oxygen species (ROS), which can cause defects in oocyte meiosis and ...
Wen Shi, Chaobin Qin, Yanyan Yang, Xiaofen Yang, Yizhen Fang, Bing Zhang, Dong Wang, Wanyou Feng, Deshun Shi   +8 more
semanticscholar   +1 more source

Ellagic Acid and the Metabolite Urolithin A Suppress HSV-1 Infection and Brain Inflammation by Targeting Casein Kinase CK2.

Journal of Agricultural and Food Chemistry
Plant-based phenolic components and their metabolites, such as ellagic acid (EA) and urolithin A (UA), possess a variety of biological activities. Here, we investigated the antiviral effect of EA and UA against HSV-1 infection, a virus that causes ...
Weikang Sun, Renjie Luo, Qingwei Qu, Jie Yang, Guang Yang, Lihua Song, Peng Cao, Erguang Li   +7 more
semanticscholar   +1 more source

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Nature Aging
Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (
Dominic Denk, Anurag Singh, Herbert G. Kasler, Davide D’Amico, Julia Rey, L. Alcober-Boquet, Johanna M. Gorol, Christoph Steup, Ritesh Tiwari, Ryan Kwok, R. Argüello, J. Faitg, K. Sprinzl, S. Zeuzem, V. Nekljudova, S. Loibl, Eric Verdin, C. Rinsch, F. Greten   +18 more
semanticscholar   +1 more source

Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway

Biochemical and Biophysical Research Communications, 2017
Ischemia/reperfusion (I/R) induces additional damage to the restoration of blood flow to ischemic myocardium. This study examined the effects of urolithin A (UA) on myocardial injury of ischemia/reperfusion in vivo and vitro and explored its underlying mechanisms. Mice were subjected to myocardial ischemia followed by reperfusion.
Lu, Tang, Yingli, Mo, Yunpeng, Li, Yongkang, Zhong, Shangfei, He, Ya, Zhang, Ying, Tang, Shanshan, Fu, Xianbao, Wang, Aihua, Chen   +9 more
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Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts

Rejuvenation Research, 2019
Although the health benefits attributed to urolithin A, such as anticancer, anti-inflammatory, and antioxidant effects, are based on numerous, diverse studies carried out in vitro , the biological effects of urolith A are still not entirely understood.
Chun-Feng, Liu, Xiao-Lin, Li, Zi-Long, Zhang, Lu, Qiu, Shi-Xuan, Ding, Jun-Xin, Xue, Guo-Ping, Zhao, Jian, Li   +7 more
openaire   +2 more sources

Modulation of renal FOXO3 gene expression by Urolithin A in a rat model of renal ischemia-reperfusion injury.

Wiadomosci lekarskie
OBJECTIVE Aim: This work uses a male Wistar Albino rat model of experimentally induced renal ischemia-reperfusion injury (IRI) to examine the nephroprotective potential of Urolithin A. PATIENTS AND METHODS Materials and Methods: Twenty-eight rats (N=7)
M. Abosaooda, Q. J. Fadheel
semanticscholar   +1 more source