Results 121 to 130 of about 2,363 (194)
Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds
Gut MicrobesThe fruits and vegetables we consume as part of our diet are rich in bioactive metabolites that can prevent and ameliorate cardiometabolic diseases, cancers, and neurological conditions. Polyphenols are a major metabolite family that has been intensively
Sara Alqudah, Jan Claesen
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A Review Study on Punica granatum L. [PDF]
, 2016 Punica granatum L (pomegranate) is a deciduous shrub, native to Iran. Nowadays, besides its use as a fruit, its medicinal properties have attracted the interest of researchers of many countries.
Bahmani, Mahmoud. +3 more
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SeparationsIn the present review, we discuss the occurrence of ellagitannins (ETs) and ellagic acid (EA) and methods for their isolation from plant materials. We summarize analytical methods, including high-performance liquid chromatography–ultraviolet (HPLC–UV ...
Christiana Mantzourani +4 more
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Potential of Urolithin A to improve joint health
Aging, 2023 D’Amico, Davide, Lotz, Martin
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Urolithin B, a newly identified regulator of skeletal muscle mass
Journal of Cachexia, Sarcopenia and Muscle, 2017 AbstractBackgroundThe control of muscle size is an essential feature of health. Indeed, skeletal muscle atrophy leads to reduced strength, poor quality of life, and metabolic disturbances. Consequently, strategies aiming to attenuate muscle wasting and to promote muscle growth during various (pathological) physiological states like sarcopenia ...
Rodriguez, Julie +7 more
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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Nature Communications, 2019 Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a ...
Rajbir Singh +20 more
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Targeting aging with urolithin A in humans: A systematic review
Ageing Research ReviewsUrolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, AH +6 more
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Efectos de la granada (Punica granatum L.) en las enfermedades inflamatorias autoinmunes [PDF]
, 2018 Las enfermedades inflamatorias autoinmunes son cada vez más comunes en nuestra sociedad, afectando a un elevado número de personas y empeorando su calidad de vida.
Martínez Carmona, María del Carmen
core
Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)
Biomedicine & PharmacotherapyCastration-resistant prostate cancer (CRPC) presents a significant challenge due to its resistance to conventional androgen deprivation therapies. Urolithins, bioactive metabolites derived from ellagitannins, have recently emerged as promising therapeutic agents for CRPC. Urolithins not only inhibit androgen receptor (AR) signaling, a crucial factor in
Ajit Kumar Navin +3 more
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