Results 31 to 40 of about 5,130,717 (259)

Prediction of poor response to ursodeoxycholic acid in patients with primary biliary cholangitis by non-invasive markers [PDF]

Xin yixue, 2023
Objective To screen non-invasive indicators for predicting poor response to ursodeoxycholic acid in patients with primary biliary cholangitis（PBC）and establish a logistic regression model.
Gao Lili, Pan Shida, Zhang Yijin, Gao Xuesong, Su Nan, Xu Li, Duan Xuefei
doaj   +1 more source

The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis

Physiological Reports, 2020
Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic acid (UDCA), to
Natalia K. Lajczak-McGinley, E. Porru, Ciara M. Fallon, J. Smyth, C. Curley, P. McCarron, M. Tambuwala, A. Roda, S. Keely   +8 more
semanticscholar   +1 more source

Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia.

Journal of Lipid Research, 1981
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3 alpha-hydroxy-7 keto-5 beta-cholanoic acid and of epimerizing it to ursodeoxycholic acid.
R Edenharder, T Knaflic
doaj   +1 more source

Oral Vancomycin, Ursodeoxycholic Acid, or No Therapy for Pediatric Primary Sclerosing Cholangitis: A Matched Analysis

Hepatology, 2020
Many children with primary sclerosing cholangitis (PSC) receive oral vancomycin therapy (OVT) or ursodeoxycholic acid (UDCA). There is a paucity of data on whether these medications improve outcomes.
M. Deneau, C. Mack, D. Mogul, E. Perito, P. Valentino, A. Amir, Matthew DiGuglielmo, L. Draijer, W. El-Matary, K. Furuya, N. Gupta, Jessica T. Hochberg, S. Horslen, M. K. Jensen, M. Jonas, N. Kerkar, B. Koot, Trevor J. Laborda, Christine K. Lee, K. Loomes, Mercedes Martinez, A. Miethke, T. Miloh, S. Mohammad, N. Ovchinsky, Girish S Rao, A. Ricciuto, P. Sathya, K. Schwarz, U. Shah, Ruchi Singh, Bernadette E Vitola, A. Zizzo, S. Guthery   +33 more
semanticscholar   +1 more source

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids

Infection and Immunity, 2020
Clostridioides difficile infection (CDI) is associated with increasing morbidity and mortality posing an urgent threat to public health. Recurrence of CDI after successful treatment with antibiotics is high, thus necessitating discovery of novel ...
Jenessa A. Winston, A. J. Rivera, Jingwei Cai, R. Thanissery, S. Montgomery, A. Patterson, C. Theriot   +6 more
semanticscholar   +1 more source

Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification

Molecules, 2023
As a first-line agent for cholestasis treatment in a clinic, ursodeoxycholic acid rectifies the perturbed bile acids (BAs) submetabolome in a holistic manner.
Wei Li, Wei Chen, Xiaoya Niu, Chen Zhao, Pengfei Tu, Jun Li, Wenjing Liu, Yuelin Song   +7 more
doaj   +1 more source

Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β‐Hydroxylation of Lithocholic Acid

Angewandte Chemie, 2020
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA).
Sascha Grobe, Christoffel P. S. Badenhorst, T. Bayer, Emil Hamnevik, Shuke Wu, Christoph W. Grathwol, A. Link, Sven Koban, Henrike Brundiek, B. Grossjohann, U. Bornscheuer   +10 more
semanticscholar   +1 more source

Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores.

Journal of Lipid Research, 1993
The biliary bile acid composition of gallbladder bile obtained from six species of bears (Ursidae), the Giant panda, the Red panda, and 11 related carnivores were determined by reversed phase liquid chromatography and gas chromatography-mass spectrometry.
LR Hagey, DL Crombie, E Espinosa, MC Carey, H Igimi, AF Hofmann   +5 more
doaj   +1 more source

Ursodeoxycholic acid: paradigmatic transformation of the prevention of drug-induced liver lesions in clinical practice [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017
In the article argued the necessity of using tactics “hepatoprotektor’s escort” in clinical practice. In it demonstrates data about new effects of Ursodeoxycholic Acid and the capabilities of its application as a universal hepatoprotector have been ...
Maksim Potjagenko, Anna Nevoit, Oksana Kitura   +2 more
doaj   +1 more source

Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review [PDF]

Beilstein Journal of Organic Chemistry, 2018
Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases.
Fabio Tonin, Isabel W. C. E. Arends
openalex   +2 more sources