Results 41 to 50 of about 5,130,717 (259)

Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy

Scientific Reports, 2020
Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic signalling.
Caroline Ovadia, Á. Perdones-Montero, H. Fan, B. Mullish, J. McDonald, G. Papacleovoulou, A. Wahlström, M. Ståhlman, Anastasia Tsakmaki, Louise C. D. Clarke, A. Sklavounos, P. Dixon, G. Bewick, J. Walters, H. Marschall, J. Marchesi, C. Williamson   +16 more
semanticscholar   +1 more source

Ursodeoxycholic acid treatment in cholesterol gallstone disease: effects on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, biliary lipid composition, and plasma lipid levels

Journal of Lipid Research, 1983
The present study was undertaken to characterize the effects of ursodeoxycholic acid on biliary lipid metabolism in man. Fifteen gallstone patients were treated with ursodeoxycholic acid at a daily dosage of 15 mg per kg body weight for about 4 weeks ...
B Angelin, S Ewerth, K Einarsson
doaj   +1 more source

Efficacy and Safety of Ursodeoxycholic Acid for the Prevention of Gallstone Formation After Gastrectomy in Patients With Gastric Cancer

JAMA Surgery, 2020
Key Points Question Can ursodeoxycholic acid administration prevent gallstone formation after gastrectomy in patients with gastric cancer? Findings In this randomized clinical trial of 521 adults, the use of 300 mg or 600 mg of ursodeoxycholic acid ...
S. Lee, D. Jang, M. Yoo, Sun-Hwi Hwang, S. Ryu, O. Kwon, H. Hur, Hong Man Yoon, B. Eom, H. Ahn, T. Son, K. Song, H. Lee, M. Choi, J. An, Sang-Il Lee, Kyung Yol Lee, Soyeon Ahn, Young Suk Park, D. Park   +19 more
semanticscholar   +1 more source

Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial

Annals of Hepatology, 2004
Objetive: Nonalcoholic fatty liver disease is an increasingly recognized condition that may progress to endstage liver disease. We investigated the effects of weight reduction and ursodeoxycholic acid administration in patients with this disease.Research
Nahum Méndez-Sánchez, Verónica González, Norberto Chávez-Tapia, Martha H Ramos, Misael Uribe   +4 more
doaj   +1 more source

Formation of delta 22-bile acids in rats is not gender specific and occurs in the peroxisome

Journal of Lipid Research, 1996
We recently demonstrated that the formation of delta 22-bile acids is a quantitatively major pathway for normal bile acid synthesis in the adult male Sprague-Dawley rat.
C M Rodrigues, B T Kren, C J Steer, K D Setchell   +3 more
doaj   +1 more source

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial

BJOG: an International Journal of Obstetrics and Gynaecology, 2020
To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA).
Jessica Fleminger, Paul Townsend Seed, Anne Smith, E. Juszczak, P. Dixon, J. Chambers, J. Dorling, C. Williamson, J. Thornton, L. Chappell   +9 more
semanticscholar   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Effectiveness and safety of obeticholic acid in a Southern European multicentre cohort of patients with primary biliary cholangitis and suboptimal response to ursodeoxycholic acid

Alimentary Pharmacology and Therapeutics, 2020
Obeticholic acid (OCA) was recently approved as the only on‐label alternative for patients with primary biliary cholangitis (PBC) with intolerance or suboptimal response to ursodeoxycholic acid (UDCA).
Elena Gomez, L. García Buey, E. Molina, M. Casado, I. Conde, M. Berenguer, F. Jorquera, M. Simón, A. Olveira, M. Hernández‐Guerra, M. Mesquita, J. Presa, P. Costa-Moreira, G. Macedo, J. Arenas, José Manuel Sousa, J. Ampuero, R. Morillas, Arsénio Santos, Armando De Carvalho, J. Uriz, J. Carrión, María Luisa Gutierrez, E. Pérez-Fernández, C. Fernández-Rodríguez   +24 more
semanticscholar   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

Efficacy and Mechanism Evaluation, 2020
Background: Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and raised serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth and neonatal unit admission.
Lucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton   +14 more
doaj   +1 more source