Results 61 to 70 of about 5,130,717 (259)

Ultrastructure of the muscular membrane of the mice gallbladder wall under the influence of ursodeoxycholic acid

Zdorovʹe Rebenka
Background. The aim of the research was to determine the ultrastructure of the cells of the muscle wall of the mice gallbladder under the influence of ursodeoxycholic acid. Materials and methods.
A.E. Abaturov, V.L. Babуch, I.V. Tverdokhlib   +2 more
doaj   +1 more source

Ursodeoxycholic acid accelerates bile acid enterohepatic circulation

British Journal of Pharmacology, 2019
Ursodeoxycholic acid (UDCA) is the first‐line treatment for primary biliary cholangitis, but its effects on the enterohepatic circulation of bile acid (BA) have been under‐investigated.
Yunjing Zhang, R. Jiang, Xiaojiao Zheng, Sha Lei, Fengjie Huang, G. Xie, S. Kwee, Herbert Yu, Christine E Farrar, Beicheng Sun, A. Zhao, Wei Jia   +11 more
semanticscholar   +1 more source

Successful treatment of an infant with congenital bile acid synthesis disorder type 3 by ursodeoxycholic acid: a case report

Journal of Medical Case Reports, 2022
Background Congenital bile acid synthesis disorder type 3 caused by oxysterol 7α-hydroxylase deficiency is an extremely rare genetic liver disease. As it may cause rapid progression to end-stage liver disease, a high cautiousness in diagnosis and early ...
Weiqian Mo, Feng Wang, Chuanen Zhou, Tinghe Ma, Zhaojun Pan, Min Xie, Haoyan Ren, Yongwu Xie   +7 more
doaj   +1 more source

Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice

Cells, 2019
Obesity has been shown to play a role in the pathogenesis of several forms of metabolic syndrome, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Yu-Sheng Chen, Hsuan-Miao Liu, Tzung-Yan Lee   +2 more
semanticscholar   +1 more source

Ursodeoxycholic acid for treatment of cholestasis in patients with hepatic amyloidosis [PDF]

Vojnosanitetski Pregled, 2009
Background. Amyloidosis represents a group of different diseases characterized by extracellular accumulation of pathologic fibrillar proteins in various tissues and organs.
Faust Dominik, Akoglu Bora, Ristić Gordana, Milović Vladan   +3 more
doaj   +1 more source

A case of idiopathic GGT elevation with acute hepatitis A

Journal of Family Medicine and Primary Care, 2019
Ursodeoxycholic acid modifies the bile acid pool and its effect on lowering liver enzymes is well documented in certain cases like chronic hepatitis but on the other hand it is known to worsen when given in advanced stages of liver disease.
Jaspreet Singh, Geoffrey Jones, David Mahan   +2 more
doaj   +1 more source

Effect of Combination Therapy with Atorvastatin and Ursodeoxycholic Acid on the Course of Ischemic Heart Disease with Co-Existent Non-Alcoholic Fatty Liver Disease and Obesity

Galician Medical Journal, 2016
Non-alcoholic fatty liver disease is considered as an independent predictor of cardiovascular diseases which plays an important role in the development of ischemic heart disease. The drug most frequently used for treating this comorbidity is atorvastatin
Nataliya Karpyshyn
doaj   +1 more source

Drug modulation of activity of microRNA generation in functional disorders of the gallbladder and sphincter of Oddi in children

Zdorovʹe Rebenka, 2019
Background. Functional disorders of the gallbladder and sphincter of Oddi are highly relevant in pediatric gastroenterology. The purpose of the study was to improve the treatment for functional disorders of the gallbladder and sphincter of Oddi in ...
A.E. Abaturov, V.L. Babich
doaj   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, EarlyView.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source