Results 81 to 90 of about 5,130,717 (259)

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Quality of life in patients with biliary tract diseases taking UDCAcontaining drug

Лечащий Врач
Background. When bile is oversaturated with cholesterol, the dynamic equilibrium between proand antinucleating factors is disturbed, which leads to precipitation of cholesterol crystals and their aggregation into microlites.
A. M. Lukmanova, A. R. Isanbaeva, G. M. Sahautdinova   +2 more
doaj   +1 more source

Optimizing treatment of atopic dermatitis in infants using ursodeoxycholic acid

Zdorovʹe Rebenka, 2017
The paper studied the rational for including of ursodeoxycholic acid suspension in complex therapy of atopic dermatitis for infants. The indication of ursodeoxycholic acid suspension for 25 infants with atopic dermatitis resulted in positive clinical ...
O.G. Shadrin, G.A. Gaiduchik
doaj   +1 more source

Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta

The FASEB Journal, 2019
Intrahepatic cholestasis of pregnancy (ICP) causes increased transfer of maternal bile acids to the fetus and an increased incidence of sudden fetal death.
E. Lofthouse, C. Torrens, A. Manousopoulou, Monica Nahar, J. Cleal, I. O'kelly, B. Sengers, S. Garbis, Rohan M. Lewis   +8 more
semanticscholar   +1 more source

Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Objective Bile acids are indispensable modulators in the development of polycystic ovary syndrome (PCOS). Our previous study identified that metformin and canagliflozin have similar efficacy in patients with PCOS combined with insulin resistance (IR).
Qi Yan, Meili Cai, Nan Wang, Wenhao Wu, Hua Zhang, Yikun Zhu, Jing Luo, Manna Zhang, Jin Li   +8 more
wiley   +1 more source

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

Frontiers in Neuroscience, 2015
Ursodeoxycholic acid and its main conjugate glycoursodeoxycholic acid are bile acids with neuroprotective properties. Our previous studies demonstrated their anti-apoptotic, anti-inflammatory and antioxidant properties in neural cells exposed to ...
Inês ePalmela, Leonor eCorreia, Rui eSilva, Rui eSilva, Hiroyuki eSasaki, Kwang Sik Kim, Dora eBrites, Dora eBrites, Maria A Brito, Maria A Brito   +9 more
doaj   +1 more source

Ursodeoxycholic Acid Alters Bile Acid and Fatty Acid Profiles in a Mouse Model of Diet-Induced Obesity

Frontiers in Pharmacology, 2019
Ursodeoxycholic acid (UDCA) is a bile acid (BA) approved by the U.S. Food and Drug Administration for the treatment of primary biliary cholangitis. It is also the major active component of bear bile used in traditional Chinese medicine to reduce fever ...
Yunjing Zhang, Xiaojiao Zheng, Fengjie Huang, A. Zhao, Kun Ge, Qing Zhao, W. Jia   +6 more
semanticscholar   +1 more source

Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis

Journal of Digestive Diseases, EarlyView.
Patients with chronic radiation enteritis (CRE) demonstrate dysregulated bile acid (BA) metabolism, characterized by an increased proportion of primary BAs and a decreased proportion of secondary BAs. Moreover, the diversity of the intestinal microbiota is significantly reduced in individuals with CRE, and there is a bidirectional interaction between ...
Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi   +9 more
wiley   +1 more source

Formation of urso- and ursodeoxy-cholic acids from primary bile acids by a Clostridium limosum soil isolate.

Journal of Lipid Research, 1984
A gram-positive, rod-shaped anaerobe (isolate F-14) was isolated from soil. This organism was identified by cellular morphology as well as by fermentative and biochemical data as Clostridium limosum.
J D Sutherland, L V Holdeman, C N Williams, I A Macdonald   +3 more
doaj   +1 more source

Integrating Dialysis in Ex Situ Machine Perfusion: A Systematic Review and Meta‐Analysis of Outcomes

Artificial Organs, EarlyView.
Dialysis‐enhanced EVMP effectively maintains biochemical homeostasis, potentially mitigating metabolic stress and extending perfusion duration. Functional outcomes varied depending on the organ type, with the most pronounced benefits observed in cardiac perfusion.
Yomna E. Dean, Sean Frisbie, James Gaston, Diwakar Phuyal, Bahareh Tabatabaei, Florian Huwyler, Matthias Pfister, Jonas Binz, Antonio Rampazzo, Gábor Szabó, Mark W. Tibbit, Pierre‐Alain Clavien, Bahar Bassiri Gharb   +12 more
wiley   +1 more source