Results 1 to 10 of about 18,987 (176)
Genetic Background Predicts Uveal Melanoma Patients' Outcomes. [PDF]
Ophthalmol SciObjective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively.
Verrier T +17 more
europepmc +2 more sources
Nature Reviews Disease Primers, 2020 Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which usually harbour a BRAF or NRAS mutation. The annual incidence in Europe and the USA is ~6 per million population per year.
Jager, M.J. +10 more
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Uveal Melanoma Metastasis [PDF]
Cancers, 2021 Uveal melanoma (UM) is characterized by relatively few, highly incident molecular alterations and their association with metastatic risk is deeply understood. Nevertheless, this knowledge has so far not led to innovate therapies for the successful treatment of UM metastases or for adjuvant therapy, leaving survival after diagnosis of metastatic UM ...
Ernesto Rossi +8 more
openaire +4 more sources
Cancers, 2019 Uveal melanoma (UM) is among the best characterized solid tumors [...]
Mariel Angelou Parulan +6 more
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Computational and Structural Biotechnology Journal, 2021 The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear.
Christine Canbezdi +7 more
doaj +1 more source
Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital [PDF]
Journal of Pathology and Translational Medicine, 2022 Background We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey. Methods This single-center study included conjunctival (n = 12) and uveal (n =
Selin Kestel +3 more
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Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases
Diagnostics, 2023 Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles.
Abin Sajan +14 more
doaj +1 more source
Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency
npj Precision Oncology, 2022 Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the ...
Thomas Chabot +18 more
doaj +1 more source
An Orthotopic Model of Uveal Melanoma in Zebrafish Embryo: A Novel Platform for Drug Evaluation
Biomedicines, 2021 Uveal melanoma is a highly metastatic tumor, representing the most common primary intraocular malignancy in adults. Tumor cell xenografts in zebrafish embryos may provide the opportunity to study in vivo different aspects of the neoplastic disease and ...
Chiara Tobia +7 more
doaj +1 more source
Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p. [PDF]
PLoS ONE, 2017 Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma.
Xiaoli Zheng +5 more
doaj +1 more source