Results 1 to 10 of about 43,652 (215)

Uveal melanoma cells utilize a novel route for transendothelial migration. [PDF]

PLoS ONE, 2014
Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial ...
Michael D Onken, Jinmei Li, John A Cooper   +2 more
doaj   +6 more sources

Genetic Background Predicts Uveal Melanoma Patients’ Outcomes [PDF]

Ophthalmology Science
Objective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively.
Thibault Verrier, PhD, Anaïs Le Ven, Alexandre Houy, Erwin Brosens, PhD, Emine Kilic, MD, PhD, Wishal D. Ramdas, MD, PhD, Tolga Bicer, MD, Agathe Garcia, PhD, Anne-Charlotte Lefranc, Sandra Vanhuele, Amanda F. Kahn, Gaelle Pierron, PhD, Alexandre Matet, MD, PhD, Nathalie Cassoux, MD, PhD, Chrystelle Colas, MD, PhD, Manuel Rodrigues, MD, PhD, Josselin Noirel, PhD, Marc-Henri Stern, MD PhD   +17 more
doaj   +2 more sources

Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

Computational and Structural Biotechnology Journal, 2021
The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear.
Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi   +7 more
doaj   +1 more source

Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital [PDF]

Journal of Pathology and Translational Medicine, 2022
Background We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey. Methods This single-center study included conjunctival (n = 12) and uveal (n =
Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem   +3 more
doaj   +1 more source

Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Diagnostics, 2023
Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles.
Abin Sajan, Samuel Fordyce, Andrew Sideris, Connie Liou, Zeeshan Toor, John Filtes, Venkatesh Krishnasamy, Noor Ahmad, Stephen Reis, Sidney Brejt, Asad Baig, Shaheer Khan, Michael Caplan, David Sperling, Joshua Weintraub   +14 more
doaj   +1 more source

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

npj Precision Oncology, 2022
Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the ...
Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues   +18 more
doaj   +1 more source

An Orthotopic Model of Uveal Melanoma in Zebrafish Embryo: A Novel Platform for Drug Evaluation

Biomedicines, 2021
Uveal melanoma is a highly metastatic tumor, representing the most common primary intraocular malignancy in adults. Tumor cell xenografts in zebrafish embryos may provide the opportunity to study in vivo different aspects of the neoplastic disease and ...
Chiara Tobia, Daniela Coltrini, Roberto Ronca, Alessandra Loda, Jessica Guerra, Elisa Scalvini, Francesco Semeraro, Sara Rezzola   +7 more
doaj   +1 more source

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +4 more sources

Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p. [PDF]

PLoS ONE, 2017
Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma.
Xiaoli Zheng, Hongwei Tang, Xiaofeng Zhao, Yamei Sun, Yanfang Jiang, Yonghua Liu   +5 more
doaj   +1 more source

Darovasertib, a novel treatment for metastatic uveal melanoma

Frontiers in Pharmacology, 2023
The FDA granted orphan drug designation to darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), for the treatment of uveal melanoma, on 2 May 2022.
Lei Cao, Shuzhen Chen, Rainie Sun, Rainie Sun, Charles R. Ashby, Liuya Wei, Zoufang Huang, Zhe-Sheng Chen   +7 more
doaj   +1 more source