Results 101 to 110 of about 123,893 (301)

Synthetic biology-inspired development of live attenuated influenza vaccines

npj Vaccines
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si   +14 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans [PDF]

, 2013
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective.
Antonopoulos, A., Britton, C., Dell, A., Dicker, A.J., Haslam, S.M., Johnston, S.L., Knox, D.P., Mcneilly, T.N., Roberts, B.   +8 more
core   +3 more sources

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

A Method for Reducing the Severity of Epidemics by Allocating Vaccines According to Centrality

, 2014
One long-standing question in epidemiological research is how best to allocate limited amounts of vaccine or similar preventative measures in order to minimize the severity of an epidemic.
Fu S., Hagberg A. A., Indrakanti S., Johnson T. V., Merrill R. M.   +4 more
core   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside

Beilstein Journal of Organic Chemistry, 2019
A series of alkyl thioglycosides and alkyl thiodiglycosides bearing glucose and N-acetylglucosamine residues were prepared by thiol–ene coupling in moderate to good yields (40–85%).
Dimitri Fayolle, Nathalie Berthet, Bastien Doumeche, Olivier Renaudet, Peter Strazewski, Michele Fiore   +5 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Redesigning Protein Function: Towards Synthetic Vaccines and MHC Mimetics

CHIMIA, 1996
Template Assembled Synthetic Proteins (TASP) approach has been applied to mimic 3D-conformations of the hen egg white lysozyme antigen (HEL) and the major histocompatibility complex (MHC) and some of their biological properties.
Gabriele Tuchscherer
doaj   +2 more sources

Research progress on emulsion vaccine adjuvants

Heliyon
Vaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than ...
Zhuanqing Huang, Hui Gong, Qi Sun, Jinjin Yang, Xiaochuan Yan, Fenghua Xu   +5 more
doaj   +1 more source