Results 111 to 120 of about 1,223,155 (304)
Advanced Science, EarlyView.Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou +11 more
wiley +1 more source
Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines
, 2017 International audienceCyclopeptides have been recently used successfully as carriers for the multivalent presentation of carbohydrate and peptide antigens in immunotherapy. Beside their synthetic versatility, these scaffolds are indeed interesting due to
Nathalie Berthet +5 more
core +1 more source
Wah Academia Journal of Health and NutritionThe post-genomic and post-pandemic era has brought about a paradigm shift in the realm of vaccinology, which has triggered a transition from empirical whole-pathogen strategies to rational information-driven molecular design.
Ali Abbas +7 more
doaj +1 more source
Advanced Science, EarlyView.A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong +13 more
wiley +1 more source
Advanced Science, EarlyView.Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv +14 more
wiley +1 more source
Assessiment of Vaccines Distribution System in Public Healthcare Facilities in Coast Region, Tanzania [PDF]
, 2012 Extended Programme on Immunization performance is among the four main indicators selected for general budget support to the health sector. The declining trend in performance of the immunization program is a major concern, routine immunization coverage in
Makuru, Mohamed, Makuru, M.
core
Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis.
, 2005 BACKGROUND: Decisions about the use of killed oral cholera vaccines, which confer moderate levels of direct protection to vaccinees, can depend on whether the vaccines also provide indirect (herd) protection when high levels of vaccine coverage are ...
Ali, Mohammad +10 more
core +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
A Model of Regulatory Burden in Technology Diffusion: The Case of Plant-Derived Vaccines. [PDF]
Plant-derived vaccines may soon displace conventional vaccines. Assuming there are no major technological barriers undermining the feasibility of this innovative technology, it is worthwhile to generate quantitative models of regulatory burden of ...
Bérard, Céline +4 more
core
A Global Perspective on Vaccines: Priorities, Challenges and Online Information
, 2020 Vaccines have been one of the most important medical discoveries of the last three centuries. Thanks to their development, millions of deaths have been avoided.
core +1 more source