Results 161 to 170 of about 1,223,155 (304)

Synthetic Neuraminidase Vaccine Induces Cross-Species and Multi-Subtype Protection

The genetic diversity of influenza A virus is a major obstacle that makes vaccine effectiveness variable and unpredictable. Objectives: Current vaccines induce strain-specific immunity that oftentimes fail to protect against divergent strains.
Adthakorn Madapong, Erika M. Petro-Turnquist, Nicholas E. Jeanjaquet, Eric A. Weaver, Enzo LaMontia-Hankin, Matthew J. Pekarek, Leigh Jahnke, Kristine V. Hoagstrom   +7 more
core   +1 more source

Editorial: Epitope Discovery and Synthetic Vaccine Design

Frontiers in Immunology, 2018
Clarisa Beatriz Palatnik-de-Sousa, Clarisa Beatriz Palatnik-de-Sousa, Irene da Silva Soares, Daniela Santoro Rosa, Daniela Santoro Rosa   +4 more
doaj   +1 more source

Toxicological evaluation of a synthetic QS-21 adjuvant in a tuberculosis vaccine candidate-Demonstrating safety and immunological equivalence to natural reference. [PDF]

Hum Vaccin Immunother
Ping H, Li Y, Ding Y, Qin L, Zou Y, Wang Y, Chen Q, Zhang Y, Zhou C, Yi Q, Liu Y.   +10 more
europepmc   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Bacterial mRNA Vaccines: Programming Immunity Against Antimicrobial Resistance. [PDF]

Drug Dev Res
Liao R, Luo M, Yang F, Xu L, Zhang J, Zhang W, Guan S, Zhang Y, Luo P, Cheng P, Yang J, Li Y, Wang Q.   +12 more
europepmc   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Immunopotentiators in modern vaccines /

, 2006
This book provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine ...
O'Hagan, Derek T., Schijns, Virgil E. J. C.   +1 more
core  

Next-generation vaccine adjuvants: Integrating nanotechnology, systems immunology, and computational approaches for precision vaccinology. [PDF]

Hum Vaccin Immunother
Zarrinpanah T, Mashhadi Abolghasem Shirazi M, Modarressi SMH, Haghighat S.   +3 more
europepmc   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Fluorinated carbohydrate-based vaccines. [PDF]

Chem Sci
Chikunova E, Suri J, Siebold K, Gilmour R.   +3 more
europepmc   +1 more source