Results 191 to 200 of about 1,223,155 (304)

Engineering the Future of Precision Medicine: A Comprehensive Guide to RNA Therapeutics. [PDF]

Curr Issues Mol Biol
Athanasopoulou K, Daneva GN, Michalopoulou VI, Stamelou MR, Tsiakanikas P, Adamopoulos PG.   +5 more
europepmc   +1 more source

Atomic clarity: how structural biology is shaping blood-stage malaria vaccines. [PDF]

Trans R Soc Trop Med Hyg
Nema S, Rathore S, Banerjee M, Zhou ZH, Mohmmed A, Malhotra P.   +5 more
europepmc   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

A Simple Method to Evaluate the Length of Poly(A) Tails in mRNA. [PDF]

Methods Protoc
Mumenthaler J, Feldmann M, Mamaghani S, Penna RR, Frei J, Jarzebska N, Mellett M, Guenova E, Kündig T, Lauchli S, Pascolo S.   +10 more
europepmc   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Chemical Synthesis and Immunological Evaluation of Escherichia coli O29, Shigella dysenteriae Serotype 11, and Proteus vulgaris O12 O-Antigen Oligosaccharides. [PDF]

Angew Chem Int Ed Engl
Li X, Wang X, Deng L, Ji X, Tu Y, Liu C, Wang Z, Wang L, Ye X, Yang Y, Zhang Q.   +10 more
europepmc   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence-Assisted Personalized Cell Membrane Nanovaccine. [PDF]

Small
Kim M, Noh I.
europepmc   +1 more source

Engineering BN‐Doped Open‐Shell Polycyclic Hydrocarbons for Enhanced Photothermal Conversion and Therapy

Angewandte Chemie International Edition, EarlyView.
Two novel bonded BN‐doped polycyclic hydrocarbons BN‐Dira and BN‐Tetra with open‐shell character were rationally designed and synthesized. Their molecular structures were unambiguously confirmed by crystallographic analysis. Facilitated by their intense absorption in the NIR region, high PCE (83.6%) and good photothermal stability, BN‐Dira and BN‐Tetra
Peiyun Zeng, Ziqi Zhuang, Huan Luo, Yubin Fu, Peiyu Wang, Yating Zheng, Gang Liu, Junzhi Liu   +7 more
wiley   +1 more source

mGem: Progress on the development of conjugate vaccines for <i>Cryptococcus neoformans</i> infections. [PDF]

mBio
Stempinski PR, Rodrigues Dos Santos Junior S, Casadevall A.   +2 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source