Results 201 to 210 of about 1,877,160 (342)

DNA Origami and Its Applications in Synthetic Biology

Advanced Science, EarlyView.
This review provides a comprehensive summary of recent advancements in DNA origami for synthetic biology, emphasizing two key areas: the precise construction and dynamic regulation of extracellular‐to‐intracellular, and the synergistic integration with cell‐free systems.
Yaning Fang, Xuexin Chen, Qingsheng Qi, Min Lin, Quanfeng Liang   +4 more
wiley   +1 more source

Total synthesis of zwitterionic PS A2 oligosaccharides from <i>Bacteroides fragilis</i>. [PDF]

Sci Adv
Li X, Pan-Gao Q, Wan Y, Zeng F, Qi J, Tu Y, Wang L, Wang Z, Codée JDC, Zhang Q.   +9 more
europepmc   +1 more source

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders

Advanced Science, EarlyView.
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
wiley   +1 more source

Advancing Peptide-Based Vaccines Against <i>Candida</i>: A Comparative Perspective on Liposomal and Synthetic Formulations. [PDF]

J Fungi (Basel)
Xin H.
europepmc   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Bacteriophages as vaccine platforms: Opportunities and challenges in translation. [PDF]

Hum Vaccin Immunother
Chen W, Peters DL, Lam S, Kettal M.
europepmc   +1 more source

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Working together: a multi-component intranasal vaccine provides synergistic protection against COVID-19. [PDF]

Signal Transduct Target Ther
Breznik JA, Verschoor CP.
europepmc   +1 more source

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma [PDF]

, 2019
Artyomov, Maxim N., Bender, Diane, Campian, Jian L., Chicoine, Michael R., Dacey, Ralph G., Dunn, Gavin P., Fritsch, Edward F., Gillanders, William E., Huang, Jiayi, Johanns, Tanner M., Kobayashi, Dale K., Liu, Connor J., Mardis, Elaine R., Miller, Christopher A., Perrin, Richard J., Schreiber, Robert D.   +15 more
core   +1 more source

Self‐Trapped Excitons in Carbon Quantum Dots with Large NIR‐II Photo‐Thermoelectric Catalysis Induce Pyroptosis for Cancer Therapy

Advanced Science, EarlyView.
The self‐trapped excitons in carbon quantum dots can serve as NIR‐II absorbers, which efficiently induce pyroptosis by driving the generation of reactive oxygen species through mild NIR‐II photothermal effect. Combined with local photophysical therapy and the cascade reaction of pyroptosis, it can activate systemic immunity and prevent tumor recurrence.
Tesen Zhang, Qingcheng Wang, Quansheng Cheng, Han Wang, He Feng, Hui Zhang, Mengbo Lin, Feili Cai, Zheng Fang, Ruo Wang, Gang Chen   +10 more
wiley   +1 more source