Results 71 to 80 of about 1,223,155 (304)

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

A synthetic adjuvant to enhance and expand immune responses to influenza vaccines.

PLoS ONE, 2010
Safe, effective adjuvants that enhance vaccine potency, including induction of neutralizing Abs against a broad range of variant strains, is an important strategy for the development of seasonal influenza vaccines which can provide optimal protection ...
Rhea N Coler, Susan L Baldwin, Narek Shaverdian, Sylvie Bertholet, Steven J Reed, Vanitha S Raman, Xiuhua Lu, Joshua DeVos, Kathy Hancock, Jacqueline M Katz, Thomas S Vedvick, Malcolm S Duthie, Christopher H Clegg, Neal Van Hoeven, Steven G Reed   +14 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

A Method for Fast, High-Precision Characterization of Synthetic Biology Devices [PDF]

, 2012
Engineering biological systems with predictable behavior is a foundational goal of synthetic biology. To accomplish this, it is important to accurately characterize the behavior of biological devices.
Weiss, Ron, Adler, Aaron, Beal, Jacob, Yaman, Fusun, Davidsohn, Noah   +4 more
core  

Clustered carbohydrates in synthetic vaccines [PDF]

Chem. Soc. Rev., 2013
Are there general rules to obtain efficient immunization against carbohydrate antigens? Thanks to technological advances in glycobiology and glycochemistry we entered a new era in which the rational design of carbohydrate vaccines has become an achievable goal.
openaire   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Characterization and Design of Synthetic Vaccines

, 2019
<p>Traditional vaccines such as live-attenuated or whole-killed vaccines have been widely used over the past hundred years. However, the safety and effectiveness of traditional vaccines have become a concern as an increasing number of people ...
Zhang,Rui
core   +1 more source

Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children. [PDF]

, 2011
BACKGROUND\ud \ud This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children.\ud \ud METHODS\ud \ud The
Machunda, E.B., Gerd Pluschke, Abdulla, Salim, Tanner, M., Daubenberger Claudia, Mpina, M., Stoffel, Sabine Alexandra, Daubenberger, C., Stoffel, S.A., Cech, P.G., Daubenberger, Claudia, Zurbriggen Rinaldo, Abdulla, S., Cech Patrick Georges, Blaise Genton, Cech, Patrick Georges, Mwanajaa Shomari Abdallah, Westerfeld Nicole, Zurbriggen, R., Stoffel Sabine Alexandra, Westerfeld, N., Tanner Marcel, Abdallah Mwanajaa Shomari, Abdulla Salim, Patrick Georges Cech, Genton, B., Pluschke, Gerd, Claudia Daubenberger, Mpina, Maxmillian, Aebi, T., Salim Abdulla, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Westerfeld, Nicole, Sabine Alexandra Stoffel, Mpina Maxmillian, Thomas Aebi, Marcel Tanner, Pluschke, G., Tanner, Marcel, Genton, Blaise, Nicole Westerfeld, Abdallah, M.S., Pluschke Gerd, Aebi, Thomas, Machunda Ester Barnabas, Genton Blaise, Ester Barnabas Machunda, Machunda, Ester Barnabas, Abdallah, Mwanajaa Shomari, Maxmillian Mpina, Aebi Thomas   +51 more
core   +2 more sources

Progress and prospect of polysaccharides as adjuvants in vaccine development

Virulence
Vaccines are an effective approach to confer immunity against infectious diseases. Modern subunit vaccines offer more precise target and safe protection compared to traditional whole-pathogen vaccines.
Xinlong Liang, Jiaying Zhou, Mengmeng Wang, Jing Wang, Houhui Song, Yigang Xu, Yuan Li   +6 more
doaj   +1 more source

Self‐Feeding Living Materials Enabled by Cell Responsive Glycogen Nanoparticles as Metabolic Batteries

Advanced Materials, EarlyView.
Glycogen is introduced as a metabolic battery that offers local and cell‐triggered release of glucose. Glycogen can be stably encapsulated into hydrogel (Dex‐TA) microcapsules that allow for diffusion of glycogen‐degrading enzymes and nutrients.
Melvin Gurian, Niels G. A. Willemen, Isa R. Porsul, Nicole Bassous, Jarno Hiemstra, Yu Na, Debby Gawlitta, Su Ryon Shin, Jeroen Leijten   +8 more
wiley   +1 more source