Results 101 to 110 of about 1,775,772 (324)

Inclusion Bodies of the Vaccinia Virus.

Experimental Biology and Medicine, 1958
SummaryTwo kinds of inclusion bodies, “A” and “B” type, exist in tissues infected with ectromelia, fowl pox and vaccinia viruses. “B” type inclusion bodies of these 3 pox group viruses have almost the same morphological and cytochemical characters. The “A” type inclusion bodies of these viruses differ according to virus and host cell.
J, KAMAHORA, Y, SATO, S, KATO, K, HAGIWARA   +3 more
openaire   +2 more sources

VRK1 Is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix

Cancer Science, EarlyView.
Small cell neuroendocrine carcinoma of the cervix (SCNEC), a rare but aggressive cancer, consistently exhibited high VRK1 expression. VRK1 knockdown significantly suppressed xenograft tumor growth by inducing mitochondrial dysfunction. These findings highlighted VRK1 as a potential therapeutic target for SCNEC.
Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei, Mizuki Kanda, Tatsuo Masuda, Mamoru Kakuda, Kosuke Hiramatsu, Tadashi Iwamiya, Tomomi Egawa‐Takata, Shinya Matsuzaki, Hiroyuki Uematsu, Kunishige Onuma, Masahiro Inoue, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +16 more
wiley   +1 more source

Susceptibility of different leukocyte cell types to Vaccinia virus infection

Virology Journal, 2004
Background Vaccinia virus, the prototype member of the family Poxviridae, was used extensively in the past as the Smallpox vaccine, and is currently considered as a candidate vector for new recombinant vaccines.
Sánchez-Puig Juana M, Sánchez Laura, Roy Garbiñe, Blasco Rafael   +3 more
doaj   +1 more source

Mpox and the Ethics of Outbreak Management: Lessons for Future Public Health Crises

Developing World Bioethics, EarlyView.
ABSTRACT Mpox, first identified in captive monkeys in 1958 and recognized in humans by 1970 in the Democratic Republic of Congo, was historically confined to sporadic zoonotic outbreaks in Central and West Africa. These outbreaks, often driven by rodent‐to‐human transmission in resource‐limited settings, reflect persistent systemic health disparities ...
Adetayo E. Obasa, Marietjie Botes, Anita Kleinsmidt, Ciara Staunton   +3 more
wiley   +1 more source

The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation. [PDF]

PLoS ONE, 2017
It has been well established that many vaccinia virus proteins suppress host antiviral pathways by targeting the transcription of antiviral proteins, thus evading the host innate immune system. However, whether viral proteins have an effect on the host's
Wondimagegnehu M Teferi, Megan A Desaulniers, Ryan S Noyce, Mira Shenouda, Brittany Umer, David H Evans   +5 more
doaj   +1 more source

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, EarlyView.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

Modified Vaccinia Virus Ankara (MVA) as Production Platform for Vaccines against Influenza and Other Viral Respiratory Diseases

Viruses, 2014
Respiratory viruses infections caused by influenza viruses, human parainfluenza virus (hPIV), respiratory syncytial virus (RSV) and coronaviruses are an eminent threat for public health.
Arwen F Altenburg, J. Kreijtz, R. D. de Vries, Fei Song, R. Fux, G. Rimmelzwaan, G. Sutter, A. Volz   +7 more
semanticscholar   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources