Results 21 to 30 of about 43,735 (192)

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers

Cancer Cell International, 2020
Background Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property.
Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou   +4 more
doaj   +1 more source

Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain.

PLoS ONE, 2012
Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus.
Hua Cao, Peihong Dai, Weiyi Wang, Hao Li, Jianda Yuan, Fangjin Wang, Chee-Mun Fang, Paula M Pitha, Jia Liu, Richard C Condit, Grant McFadden, Taha Merghoub, Alan N Houghton, James W Young, Stewart Shuman, Liang Deng   +15 more
doaj   +1 more source

Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody. [PDF]

PLoS ONE, 2012
Virotherapy using oncolytic vaccinia virus (VACV) strains is one promising new strategy for cancer therapy. We have previously reported that oncolytic vaccinia virus strains expressing an anti-VEGF (Vascular Endothelial Growth Factor) single-chain ...
Sandeep S Patil, Ivaylo Gentschev, Marion Adelfinger, Ulrike Donat, Michael Hess, Stephanie Weibel, Ingo Nolte, Alexa Frentzen, Aladar A Szalay   +8 more
doaj   +1 more source

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj   +1 more source

Virulence in murine model shows the existence of two distinct populations of Brazilian Vaccinia virus strains. [PDF]

PLoS ONE, 2008
Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact.
Jaqueline Maria Siqueira Ferreira, Betânia Paiva Drumond, Maria Isabel Maldonado Coelho Guedes, Marcelo Antônio Pascoal-Xavier, Camila Megale Almeida-Leite, Rosa Maria Esteves Arantes, Bruno Eduardo Fernandes Mota, Jônatas Santos Abrahão, Pedro Augusto Alves, Fernando Meireles Oliveira, Paulo César Peregrino Ferreira, Cláudio Antônio Bonjardim, Zélia Inês Portela Lobato, Erna Geessien Kroon   +13 more
doaj   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

mBio, 2023
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza, Annika Brinkmann, José Esparza, Andreas Nitsche, Clarissa R. Damaso   +4 more
doaj   +1 more source

Respiratory infection due to direct contact with rabbit-skin powder contaminated by vaccinia virus

International Journal of Infectious Diseases, 2018
Vaccinia virus infection was diagnosed in five male workers directly exposed to rabbit-skin powder contaminated by vaccinia virus via skin contact and inhalation. Four of the workers had been vaccinated against smallpox.
Zhigang Hu, Xue Yang, Shaoxia Zhuang, Jie Liu   +3 more
doaj   +1 more source

Route-coupled pathogenicity and immunogenicity of vaccinia virus variant inoculated mice

Инфекция и иммунитет, 2021
Vaccinia virus had played a key role in the global smallpox eradication. However, in case of mass vaccination with various Vaccinia virus strains severe side effects were revealed sometimes ending up with lethal outcomes, especially in immunocompromised ...
S. N. Shchelkunov, A. A. Sergeev, A. S. Kabanov, S. N. Yakubitskyi, T. V. Bauer, S. A. Pyankov   +5 more
doaj   +1 more source

Detection of Vaccinia Virus in Dairy Cattle Serum Samples from 2009, Uruguay

Emerging Infectious Diseases, 2016
We detected orthopoxvirus in 28 of 125 serum samples collected during 2009 from cattle in Uruguay. Two samples were PCR-positive for vaccinia virus and had sequences similar to those for vaccinia virus associated with outbreaks in Brazil.
Ana Paula Moreira Franco-Luiz, Danilo Bretas Oliveira, Alexandre Fagundes Pereira, Mirela Cristina Soares Gasparini, Cláudio Antônio Bonjardim, Paulo César Peregrino Ferreira, Giliane de Souza Trindade, Rodrigo Puentes, Agustin Furtado, Jônatas Santos Abrahão, Maurício Teixeira Lima   +10 more
doaj   +1 more source

PCR-Based Method for the Introduction of Mutations in Genes Cloned and Expressed in Vaccinia Virus

BioTechniques, 1998
Vaccinia virus expression systems allow efficient expression of genes and facilitate functional studies of expressed proteins in cultured mammalian cells.
María del Mar Lorenzo, Rafael Blasco
doaj   +1 more source