Results 41 to 50 of about 1,775,772 (324)

Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody. [PDF]

PLoS ONE, 2012
Virotherapy using oncolytic vaccinia virus (VACV) strains is one promising new strategy for cancer therapy. We have previously reported that oncolytic vaccinia virus strains expressing an anti-VEGF (Vascular Endothelial Growth Factor) single-chain ...
Sandeep S Patil, Ivaylo Gentschev, Marion Adelfinger, Ulrike Donat, Michael Hess, Stephanie Weibel, Ingo Nolte, Alexa Frentzen, Aladar A Szalay   +8 more
doaj   +1 more source

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H., Loh, Lambert C., Lucin, Pero, Messerle, Martin, Rapp, Maria   +4 more
core   +1 more source

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection

Journal of Virology, 2019
Poxviruses are large DNA viruses that can infect a wide range of host species. A number of these viruses are clinically important to humans, including variola virus (smallpox) and vaccinia virus.
R. Luteijn, Ferdy R. van Diemen, V. Blomen, I. G. Boer, Saravanan Manikam Sadasivam, T. V. van Kuppevelt, I. Drexler, T. Brummelkamp, R. Lebbink, E. Wiertz   +9 more
semanticscholar   +1 more source

Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]

, 2010
This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M., Carter, P. E., Collins-Emerson, J. M., French, N. P., Hathaway, S., Marshall, J., Midwinter, A. C., Mullner, P., Pirie, R., Shadbolt, T., Spencer, Simon E. F., Wilson, D. J.   +11 more
core   +1 more source

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj   +1 more source

Virulence in murine model shows the existence of two distinct populations of Brazilian Vaccinia virus strains. [PDF]

PLoS ONE, 2008
Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact.
Jaqueline Maria Siqueira Ferreira, Betânia Paiva Drumond, Maria Isabel Maldonado Coelho Guedes, Marcelo Antônio Pascoal-Xavier, Camila Megale Almeida-Leite, Rosa Maria Esteves Arantes, Bruno Eduardo Fernandes Mota, Jônatas Santos Abrahão, Pedro Augusto Alves, Fernando Meireles Oliveira, Paulo César Peregrino Ferreira, Cláudio Antônio Bonjardim, Zélia Inês Portela Lobato, Erna Geessien Kroon   +13 more
doaj   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

mBio, 2023
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza, Annika Brinkmann, José Esparza, Andreas Nitsche, Clarissa R. Damaso   +4 more
doaj   +1 more source

Respiratory infection due to direct contact with rabbit-skin powder contaminated by vaccinia virus

International Journal of Infectious Diseases, 2018
Vaccinia virus infection was diagnosed in five male workers directly exposed to rabbit-skin powder contaminated by vaccinia virus via skin contact and inhalation. Four of the workers had been vaccinated against smallpox.
Zhigang Hu, Xue Yang, Shaoxia Zhuang, Jie Liu   +3 more
doaj   +1 more source

Route-coupled pathogenicity and immunogenicity of vaccinia virus variant inoculated mice

Инфекция и иммунитет, 2021
Vaccinia virus had played a key role in the global smallpox eradication. However, in case of mass vaccination with various Vaccinia virus strains severe side effects were revealed sometimes ending up with lethal outcomes, especially in immunocompromised ...
S. N. Shchelkunov, A. A. Sergeev, A. S. Kabanov, S. N. Yakubitskyi, T. V. Bauer, S. A. Pyankov   +5 more
doaj   +1 more source

Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]

, 2009
Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S., Wang, Nan, Weber, Ekkehard   +2 more
core   +1 more source