Results 81 to 90 of about 1,739,286 (305)

First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.

Molecular Therapy, 2015
Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity.
Herbert J. Zeh, Stephanie Downs-Canner, J. McCart, Zongbi Guo, Uma N M Rao, Lekshmi Ramalingam, Stephen H Thorne, H. Jones, P. Kalinski, E. Wieckowski, M. O’Malley, M. Daneshmand, K. Hu, John C. Bell, T. Hwang, A. Moon, C. Breitbach, D. Kirn, David L. Bartlett   +18 more
semanticscholar   +1 more source

Vaccinia and Pox-Virus

, 2007
Vaccinia virus has been studied extensively since its discovery as a smallpox vaccine in 1798. Its use as a smallpox vaccine documented its safety profile. It was later found that its large size and ability to accept large fragments of DNA combined with its natural tumor affinity make it an attractive agent for cancer therapy.
Sricharan Chalikonda, David L. Bartlett
openaire   +2 more sources

Optical Method for the Detection of Viral RNA Using an Optical Fiber Sensor

Journal of Biophotonics, EarlyView.
This study presents a fiber‐optic sensor with a microsphere tip functionalized with a gold layer and oligonucleotide probes for detecting SARS‐CoV‐2 RNA at concentrations as low as 10−12 M in near real time. ABSTRACT This study introduces a fiber‐optic sensor functionalized with a sensing probe for SARS‐CoV‐2 RNA detection.
Patryk Sokołowski, Paweł Wityk, Joanna Raczak‐Gutknecht, Wiktoria Brzezińska, Michał Sobaszek, Paweł Kalinowski, Sebastian Garcia‐Galan, Małgorzata Szczerska   +7 more
wiley   +1 more source

Human vaccinia-like virus outbreaks in São Paulo and Goiás States, Brazil: virus detection, isolation and identification Surtos de vírus Vaccinia-like nos Estados de São Paulo e Goiás, Brasil: detecção, isolamento e identificação viral

Revista do Instituto de Medicina Tropical de São Paulo, 2004
Since October 2001, the Adolfo Lutz Institute has been receiving vesicular fluids and scab specimens of patients from Paraíba Valley region in the São Paulo and Minas Gerais States and from São Patricio Valley, in the Goiás State.
Teresa Keico Nagasse-Sugahara, Jonas José Kisielius, Marli Ueda-Ito, Suely Pires Curti, Cristina Adelaide Figueiredo, Áurea Silveira Cruz, Maysa Madalena J. Silva, Carmen Helena Ramos, Maria Claudia C. Silva, Tiyo Sakurai, Luis Florêncio Salles-Gomes   +10 more
doaj   +1 more source

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

Proceedings of the National Academy of Sciences of the United States of America, 1986
DNA coding for bacteriophage T7 RNA polymerase was ligated to a vaccinia virus transcriptional promoter and integrated within the vaccinia virus genome.
T. Fuerst, E. G. Niles, F. Studier, B. Moss   +3 more
semanticscholar   +1 more source

Studies on the Cultivation of the Virus of Vaccinia [PDF]

Journal of Infectious Diseases, 1913
n ...
Steinhardt, E., Israeli, C., Lambert, R. A.   +2 more
openaire   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Ertl, H., Koszinowski, Ulrich H.
core  

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

In-vitro demonstration of cell-mediated immunity to vaccinia virus in man [PDF]

, 1975
Cell mediated immunity to vaccinia virus in man was studied by lymphocyte transformation. Vaccinia antigen, propagated on BHK-21 and Vero cells, could be used successfully for in-vitro testing after partial purification as well as crude infectious ...
Koszinowski, Ulrich H., Thomssen, R., Volkmann, B.   +2 more
core