Results 31 to 40 of about 441,117 (305)

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

mBio, 2016
Toxoplasma gondii is an obligate intracellular parasite that invades host cells and replicates within a unique parasitophorous vacuole. To maintain this intracellular niche, the parasite secretes an array of dense granule proteins (GRAs) into the nascent
S. Nadipuram, Elliot W. Kim, A. Vashisht, Andrew H. Lin, Hannah N. Bell, I. Coppens, J. Wohlschlegel, P. Bradley   +7 more
semanticscholar   +1 more source

Arabidopsis myosin XI sub-domains homologous to the yeast myo2p organelle inheritance sub-domain target subcellular structures in plant cells

Frontiers in Plant Science, 2013
Myosin XI motor proteins transport plant organelles on the actin cytoskeleton. The Arabidopsis gene family that encodes myosin XI has 13 members, 12 of which have sub-domains within the tail region that are homologous to well-characterized cargo-binding ...
Amirali eSattarzadeh, Amirali eSattarzadeh, Maureen eHanson, Elmon eSchmelzer   +3 more
doaj   +1 more source

Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in Saccharomyces cerevisiae

Frontiers in Microbiology, 2020
Hydrofluoric acid elicits cell cycle arrest through a mechanism that has long been presumed to be linked with the high affinity of fluoride to metals.
Nichole R. Johnston, Sunitha Nallur, Patricia B. Gordon, Kathryn D. Smith, Scott A. Strobel, Scott A. Strobel   +5 more
doaj   +1 more source

The Evolution of Leaf Function during Development Is Reflected in Profound Changes in the Metabolic Composition of the Vacuole

Metabolites, 2021
During its development, the leaf undergoes profound metabolic changes to ensure, among other things, its growth. The subcellular metabolome of tomato leaves was studied at four stages of leaf development, with a particular emphasis on the composition of ...
Alice Destailleur, Théo Poucet, Cécile Cabasson, Ana Paula Alonso, Jean-Christophe Cocuron, Romain Larbat, Gilles Vercambre, Sophie Colombié, Pierre Petriacq, Marie Hélène Andrieu, Bertrand Beauvoit, Yves Gibon, Martine Dieuaide-Noubhani   +12 more
doaj   +1 more source

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

Journal of Cell Biology, 2015
Cytological and biochemical analyses show that Ylr072w, here renamed Lipid transfer at contact site 1 (Ltc1), is a sterol transport protein localized to both ER–mitochondria and ER–vacuole contact sites in partnership with the organelle-specific ...
Andrew Murley, R. Sarsam, Alexandre Toulmay, Justin Yamada, W. Prinz, J. Nunnari   +5 more
semanticscholar   +1 more source

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Journal of Cell Biology, 2000
Autophagy and the Cvt pathway are examples of nonclassical vesicular transport from the cytoplasm to the vacuole via double-membrane vesicles. Apg8/Aut7, which plays an important role in the formation of such vesicles, tends to bind to membranes in spite
T. Kirisako, Yoshinobu Ichimura, H. Okada, Y. Kabeya, N. Mizushima, T. Yoshimori, M. Ohsumi, T. Takao, Takeshi Noda, Y. Ohsumi   +9 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The changing nature of the Brucella‐containing vacuole

Cellular Microbiology, 2015
Bacteria of the genus Brucella are intracellular vacuolar pathogens of mammals that cause the worldwide zoonosis brucellosis, and reside within phagocytes of infected hosts to promote their survival, persistence and proliferation.
J. Celli
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

eLife, 2015
Sumoylation during genotoxic stress regulates the composition of DNA repair complexes. The yeast metalloprotease Wss1 clears chromatin-bound sumoylated proteins.
Maxim Y Balakirev, James E Mullally, Adrien Favier, Nicole Assard, Eric Sulpice, David F Lindsey, Anastasia V Rulina, Xavier Gidrol, Keith D Wilkinson   +8 more
doaj   +1 more source