Results 91 to 100 of about 359,848 (297)

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, EarlyView.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source

Efterlevnad av beslut om djurförbud hos hållare av sällskapsdjur och lantbruksdjur i Västra Götalands län [PDF]

, 2013
Denna studie riktar sig främst till länsstyrelsen i Västra Götalands län, som var frågeställare, men också till de andra länsstyrelserna i landet. Syftet var att undersöka hur de personer som på något sätt orsakat lidande hos djur och därför blivit ...
Ringström, Anna
core   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

An evaluation of the accuracy of some radar wind profiling techniques [PDF]

, 1983
Major advances in Doppler radar measurement in optically clear air have made it feasible to monitor radial velocities in the troposphere and lower stratosphere.
Doviak, R. J., Koscielny, A. J.
core   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

GDF10 Regulates Iron‐Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang, Tianying Huang, Dan Xie, Hailin Xiong   +3 more
wiley   +1 more source

Surveillance of Phenibut in Wastewater During a Brazilian Carnival

Drug Testing and Analysis, EarlyView.
This study reports the first detection of phenibut in Brazilian wastewater. Phenibut, a substance readily sold online to improve concentration, reaches wastewater treatment plants (WWTPs) after consumption by the population. Samples from WWTPs in the cities of Recife and Olinda in Northeastern Brazil were collected during the world's largest Carnival ...
Bruna R. de S. Gomes, Ana Flávia B. de Oliveira, Aline de Melo Vieira, Dhayaalini Nadarajan, Richard Bade, Jandyson M. Santos   +5 more
wiley   +1 more source

Correlation study of Framingham risk score and vascular dementia

Medicine, 2017
Vascular dementia (VaD) is one of the most common forms of dementia, and second only to Alzheimer's disease. The purpose of this study was to evaluate the potential diagnostic value of Framingham risk score (FRS) in VaD by investigating the relationship ...
Shan-Shan Li, Jie Zheng, Bin Mei, Han-Yao Wang, M. Zheng, Kai Zheng   +5 more
semanticscholar   +1 more source

The world's oldest man‐made biological experiment

Ecography, EarlyView.
Biological experiments are often short‐lived due to logistical or resource‐related challenges, and short‐term observations are extrapolated to make long‐term predictions. However, the effects of experimental treatments on biological communities and processes take time to develop.
Laura Käse, Chanvilay Somvongsa, Khamla Inkhavilay, Claus Christensen, Lars Lønsmann Iversen, Ole Pedersen, Lars Baastrup‐Spohr   +6 more
wiley   +1 more source

Predisposing factors and radiological features in patients with internal carotid artery dissection or vertebral artery dissection

BMC Neurology, 2020
Background Cervicocerebral artery dissection is an important cause of ischemic stroke in young and middle-aged individuals. However, very few studies have compared the differential features between internal carotid artery dissection (ICAD) and vertebral ...
Yongjun Wu, Hongbin Chen, Shihui Xing, Shuangquan Tan, Xinran Chen, Yan Tan, Jinsheng Zeng, Jian Zhang   +7 more
doaj   +1 more source