Results 61 to 70 of about 43,537 (271)

Lättlästa bearbetningar –vad försvinner och vad blir kvar?

Publikationer från Örebro universitet, 2021
Studien ämnar belysa skillnaden mellan originalversion och lättläst version av två klassiska barn- och ungdomsböcker. Böckerna som analyserats är Mästerdetektiven Blomkvist av Astrid Lindgren och Tordyveln flyger i skymningen av Maria Gripe. Studiens syfte är att visa hur berättelsen förändras mellan originalversion och lättläst version i dessa ...
Lidell, Magnus, Nilsson, Emma
openaire   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Predisposing factors and radiological features in patients with internal carotid artery dissection or vertebral artery dissection

BMC Neurology, 2020
Background Cervicocerebral artery dissection is an important cause of ischemic stroke in young and middle-aged individuals. However, very few studies have compared the differential features between internal carotid artery dissection (ICAD) and vertebral ...
Yongjun Wu, Hongbin Chen, Shihui Xing, Shuangquan Tan, Xinran Chen, Yan Tan, Jinsheng Zeng, Jian Zhang   +7 more
doaj   +1 more source

Real‐Time, Label‐Free Classification of Cell Death Pathways via Holotomography‐Based Deep Learning Framework

Advanced Intelligent Systems, EarlyView.
A 3D holotomography system coupled with a deep learning model distinguishes how cells die—apoptosis, necroptosis or necrosis—without any fluorescent labels. Training on refractive index maps of HeLa cells yields 97% accuracy and flags necroptosis hours before chemical dyes.
Minwook Kim, Wei Sun Park, Geon Kim, Sanggeun Oh, Jaephil Do, Juyeon Park, Jihwan Yu, Won Do Heo, YongKeun Park   +8 more
wiley   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Medin, an aging‐associated amyloidogenic protein, induces cerebrovascular dysfunction and inflammation. We investigated the relationship between cerebrovascular medin and Alzheimer's disease (AD) and vascular dementia (VaD). Methods Cerebral
Raymond Q. Migrino, Nina Karamanova, Seth Truran, Geidy E. Serrano, Hannah A. Davies, Jillian Madine, Thomas G. Beach   +6 more
doaj   +1 more source

Surveillance of Phenibut in Wastewater During a Brazilian Carnival

Drug Testing and Analysis, EarlyView.
This study reports the first detection of phenibut in Brazilian wastewater. Phenibut, a substance readily sold online to improve concentration, reaches wastewater treatment plants (WWTPs) after consumption by the population. Samples from WWTPs in the cities of Recife and Olinda in Northeastern Brazil were collected during the world's largest Carnival ...
Bruna R. de S. Gomes, Ana Flávia B. de Oliveira, Aline de Melo Vieira, Dhayaalini Nadarajan, Richard Bade, Jandyson M. Santos   +5 more
wiley   +1 more source

The impact of metal cup size on neonatal and maternal morbidity in vacuum‐assisted deliveries

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate whether metal cup size influences maternal and neonatal morbidity in vacuum‐assisted deliveries (VAD). Materials and Methods Retrospective cohort at a single tertiary center (2011–2022) comparing 60‐mm versus 50‐mm Malmström cups. A 1:1 matched cohort analysis balanced maternal and obstetric variables.
Matan Anteby, Tally Pinchas‐Cohen, Yoav Baruch, Anat Lavie, Sharon Maslovitz, Liran Hiersch, Yariv Yogev   +6 more
wiley   +1 more source