Results 61 to 70 of about 31,199 (169)

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

Doing Age and Aged Doings in 10–12‐Year‐Olds' Descriptions of Their Leisure Opportunities

Children &Society, EarlyView.
ABSTRACT The aim of this study is to contribute knowledge about how children aged 10 to 12 describe their leisure time, and how their accounts of what they do, what they want to do, and what they perceive as available to them can be understood in relation to age as a social category.
Lina Lago, Sanna Hedrén
wiley   +1 more source

Neuropsychiatric symptoms in patients with vascular dementia in mainland China

Translational Neuroscience, 2015
Background: Neuropsychiatric deficits can induce marked disability in patients with dementia and increase caregiver distress. Several studies have found that neuropsychiatric symptoms are common both in patients with Alzheimer’s disease (AD) and patients
Jin Yan-ling, Zhang Hong, Gao Yong-zhe, Shu Min, Xu Yan, Liu Xi, Zhang Sheng-ming, Zou Chao-yu, Cao Jing, Xiong Rong-hong   +9 more
doaj   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Dementia Risk in Type 1 and 2 Diabetes: A Nationwide Population‐Based Comparison

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes is increasingly recognised as a major contributor to cognitive decline and dementia, but the risk varies by diabetes type and treatment intensity. We compared the risk of all‐cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD) among individuals with and without diabetes.
Ji Eun Jun, Seohyun Kim, In‐Kyung Jeong, Jae Hyeon Kim   +3 more
wiley   +1 more source

The Ventricular Assist Device team in the management of patients treated with long-term Mechanical Circulatory Support

Infermieristica Journal
The number of people with heart failure is increasing rapidly worldwide. Despite preventive measures, optimal medical therapy, and cardiac transplantation, the overall morbidity and mortality of this syndrome remain high.
Simone Amato, Andrea Battisti, Daniele Napolitano   +2 more
doaj   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Unveiling Disparities and Missed Opportunities in Vitamin A Supplementation Among Children Under Five in Ethiopia

Maternal &Child Nutrition, EarlyView.
Vitamin A supplementation (VAS) coverage in Ethiopia remains low (21%), with substantial inequities favoring wealthier, urban, and agrarian households, and missed opportunities to integrate VAS with health services like measles vaccination. Improving coverage, equity, and resilience requires expanding access, tailoring delivery approaches, and ...
Tsedey Moges, Meron Girma, Alemnesh Petros, Nardos Birru, Alemayehu Hussen, Meseret Woldeyohannes, Abiy Tefera, Tadesse Kebebe, Berhanu Wodajo, Getachew Tollera, Mesay Hailu, Stanley Chitekwe, Hiwot Darsene, Kidist Woldesenbet, Kaleab Baye, Masresha Tessema, Ramadhani Noor   +16 more
wiley   +1 more source

Vad är omvårdnad och vad är det inte?

Sömn och Hälsa
I juni 2025 presenterade International Council of Nurses (ICN) en ny, uppdaterad definition av både nurse och nursing. Behovet av att definiera professionen är i sig inget nytt.
Pernilla Garmy
doaj   +1 more source

Pro‐Vitamin A Biofortified Cavendish Banana: Trait Stability in the Field

Plant Biotechnology Journal, EarlyView.
ABSTRACT Vitamin A deficiency (VAD), a major global health concern, has driven efforts to develop staple crops with enhanced pro‐vitamin A (pVA) content. Delivering meaningful nutritional benefits, however, requires technologies that maintain elevated carotenoid levels under field conditions. Previous proof‐of‐concept work demonstrated that pVA content
Jimmy M. Tindamanyire, Jacinta L. Watkins, Cara Mortimer, Bulukani Mlalazi, Jeff Daniells, Rob Harding, James L. Dale, Jean‐Yves Paul   +7 more
wiley   +1 more source