Results 231 to 240 of about 154,188 (306)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Multistep metabolic engineered <i>Klebsiella oxytoca</i> for efficient l-leucine production. [PDF]

Synth Syst Biotechnol
Sun W, Yang Q, Wang S, Gong L, Zhou Z, Liu M, Tan X, Kang Q, Meng W, Liu Y, Kang Z, Xu P, Ma C, Gao C, Lü C.   +14 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Two new factors modulating <i>Bacillus subtilis</i> spore resistance and germination. [PDF]

mSphere
Bannon WJ, Padilla D, Suryadevara D, Ye F, Korza G, Wicander J, Setlow P.   +6 more
europepmc   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source

An exploratory investigation of β-aminoisobutyric acid as a biomarker: possible relationships between urinary BAIBA and lifestyle habits. [PDF]

Biochem Biophys Rep
Suzuki M, Shimba Y, Sakai A, Kobayashi A, Shibayama S, Takahashi C, Shibata M, Kiyosawa T, Obana Y, Yamada Y, Hosaka T.   +10 more
europepmc   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Effects of <i>Allium mongolicum</i> Essential Oil on Meat Quality and Flavor-Related Free Amino Acids in Finishing Lambs. [PDF]

Animals (Basel)
Erdene K, Wang X, Zhao Y, Cao Q, Zheng Y, Ao C, Bai C.   +6 more
europepmc   +1 more source

Consistency of c‐Met protein overexpression over time in patients with non‐squamous non‐small cell lung cancer

Histopathology, EarlyView.
c‐Met protein overexpression can be assessed before or after treatment in patients with non‐squamous NSCLC since most patients maintain a consistent c‐Met status. However, as targeted therapies may elevate c‐Met overexpression, retesting may be necessary for subsets of patients.
Alexis B Cortot, Romain Dubois, Valérie Grégoire, Jean‐Baptiste Gibier, Julien Labreuche, Virginie Deprez, Déborah Dubrulle, Thomas Chretien, Eric Wasielewski, Hélène Behal, Dai Feng, Amber Lind, Peter Ansell, Raphaële Thiébaut‐Millot, Carlos Hader   +14 more
wiley   +1 more source

Early-life adversity induces metabolic alterations in a rodent model of depression: a differential stress response perspective. [PDF]

Acta Neuropsychiatr
van Rensburg DJ, Lindeque Z, Whitney AJ, Steyn SF.   +3 more
europepmc   +1 more source