Results 71 to 80 of about 225,375 (330)

The Effect of Dexamethasone-Mediated Atrophy on Mitochondrial Function and BCAA Metabolism During Insulin Resistance in C2C12 Myotubes

Metabolites
Background: Muscle loss during sarcopenia and atrophy is also commonly associated with age-related insulin resistance. Interestingly, branched-chain amino acids (BCAA) which are known for stimulating muscle protein synthesis are commonly elevated during ...
Kayla J. Ragland, Kipton B. Travis, Emmalie R. Spry, Toheed Zaman, Pamela M. Lundin, Roger A. Vaughan   +5 more
doaj   +1 more source

Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]

, 2016
Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido, Eeckhaut, Venessa, Hesta, Myriam, Janssens, Geert, Junius, Greet, Liu, Daisy, Niu, Yufeng, Ribeiro Alves Lourenço, Marta, Van de Maele, Isabel, Van de Wiele, Tom, Van Immerseel, Filip, Verbrugghe, Adronie, Wuyts, Brigitte, Xu, Jia   +13 more
core   +2 more sources

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?

Journal of the International Society of Sports Nutrition, 2017
The branched chain amino acids (BCAAs) are leucine, valine and isoleucine. A multi-million dollar industry of nutritional supplements has grown around the concept that dietary supplements of BCAAs alone produce an anabolic response in humans driven by a ...
Robert R. Wolfe
doaj   +1 more source

Multienzyme (3‐in‐1)‐Mimicking a Single Nucleobase‐Derived Bionanozyme for Versatile Environmental and Biomedical Applications

Advanced Healthcare Materials, EarlyView.
This study reports the development of bioinspired 2D crystalline Bionanozyme derived from a single nucleobase. It effectively mimics multienzyme activity to detect and remove phenolic pollutants, identify disease biomarkers with high sensitivity, and protect cells from oxidative stress.
Subrat Vishwakarma, Om Shanker Tiwari, Durba Banerjee, Linda J. W. Shimon, Amit Israelstam, Ilia Kaminker, Sudip Mukherjee, Ehud Gazit, Pandeeswar Makam   +8 more
wiley   +1 more source

Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. [PDF]

, 2019
Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to cognate tRNA molecules, which are required for protein translation. To date, biallelic mutations in 31 ARS genes are known to cause recessive, early-onset severe multi-organ diseases ...
Accogli, Andrea, Ben-Omran, Tawfeg, Bernard, Geneviève, Chowdhury, Shimul, Crawford, John R, Dimmock, David, Friedman, Jennifer, Gleeson, Joseph G, Guerrero, Kether, Hildreth, Amber, Issa, Mahmoud Y, James, Kiely N, Kingsmore, Stephen F, Koehler, Alanna E, Lo, Wing-Sze, Mendes, Marisa I, Musaev, Damir, Nahas, Shareef, Omar, Tarek EI, Salomons, Gajja S, Smith, Desiree E, Stanley, Valentina, Tran, Luan T, Wang, Rengang, Wigby, Kristen, Wright, Meredith S, Xu, Zhiwen, Zaki, Maha S, Zhai, Liting   +28 more
core   +2 more sources

A Multifunctional Binder for Current‐Collector‐Free Zn Powder Anodes

Advanced Materials, EarlyView.
By introducing abundant polar groups as Zn2+ absorption sites and hydrogen bond arrays, a protein structure‐derived binder for ZP anode and iodine cathode is proposed. This design can regulate the Zn2+ flux, benefit the formation of free‐standing electrode, inhibit the side reactions, suppress the shuttle effect of polyiodides, and enable the large ...
Yanbo Wang, Xintao Ma, Xinru Yang, Rong Zhang, Hu Hong, Shixun Wang, Qing Li, Ze Chen, Zhaodong Huang, Haiming Lv, Chunyi Zhi   +10 more
wiley   +1 more source

Asymmetric amplification in amino acid sublimation involving racemic compound to conglomerate conversion [PDF]

, 2011
A straightforward unprecedented sublimation protocol that reveals both conversion of a racemic compound into a racemic conglomerate and subsequent enantioenrichment has been developed for the proteinogenic amino acid valine.
Cintas, Pedro, Noorduin, Wim L., Ortiz Menéndez, José Eugenio, Torres Pérez-Hidalgo, Trinidad José, Viedma, Cristobal   +4 more
core   +4 more sources

5-Valine-oxytocin and 1-Deamino-5-valine-oxytocin [PDF]

Journal of Biological Chemistry, 1966
Abstract The paper reports the syntheses of 5-valine-oxytocin and 1-deamino-5-valine-oxytocin, analogues of oxytocin and 1-deamino-oxytocin which contain a valine residue in place of the asparagine residue in position 5. On assay for biological activity, 5-valine-oxytocin was found to possess approximately 0.3 unit per mg of oxytocic activity and 0.1 ...
Irving L. Schwartz, Roderich Walter
openaire   +2 more sources

Topology in Biological Piezoelectric Materials

Advanced Materials, EarlyView.
This review summarizes the topological structures in biological piezoelectric materials, covering morphology evolution, spatial arrangement, and biomimetic strategies. These topologies modulate structure‐property relationships across multiple scales, enabling performance enhancement and multifunctional integration.
Chen Chen, Yanhu Zhang, Yi Zheng, Yi Zhang, Hongyi Liu, Jiang Wu, Liang Yang, Zhengbao Yang   +7 more
wiley   +1 more source