The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability [PDF]
MicroorganismsBacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival mechanisms during stress conditions. In regular environmental conditions, the antitoxin blocks the toxin, whereas during imbalanced conditions, the antitoxin ...
Deborah K. Damiano +6 more
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Focused Overview of Mycobacterium tuberculosis VapBC Toxin–Antitoxin Systems Regarding Their Structural and Functional Aspects: Including Insights on Biomimetic Peptides [PDF]
Biomimetics, 2023 Tuberculosis, caused by Mycobacterium tuberculosis, is a lethal infectious disease of significant public health concern. The rise of multidrug-resistant and drug-tolerant strains has necessitated novel approaches to combat the disease.
Sung-Min Kang
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system [PDF]
mBioToxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division.
Sarah Hollingshead +10 more
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Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolatedShigella flexneriVapC toxin [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013 Upon release from the stable complex formed with its antitoxin VapB, the toxin VapC (MvpT) of the Gram-negative pathogen Shigella flexneri is capable of globally down-regulating translation by specifically cleaving initiator tRNA(fMet) in the anticodon region.
Xu K +7 more
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Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking
Nucleic Acids Research, 2012 Toxin-antitoxin (TA) loci encode inhibitors of translation, replication or cell wall synthesis and are common elements of prokaryotic plasmids and chromosomes. Ten TA loci of Escherichia coli K-12 encode mRNases that cumulatively contribute to persistence (multidrug tolerance) of the bacterial cells. The mechanisms underlying induction and reversion of
Winther KS, Gerdes K
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Apoptosis like symptoms associated with abortive infection of Mycobacterium smegmatis by mycobacteriophage D29. [PDF]
PLoS ONE, 2022 Mycobacteriophages are phages that infect mycobacteria resulting in their killing. Although lysis is the primary mechanism by which mycobacteriophages cause cell death, others such as abortive infection may also be involved.
Fatema Calcuttawala +5 more
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Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria [PDF]
Malaria Journal, 2023 Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control.
Alima Qureshi, John B. Connolly
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Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [PDF]
Infection and ImmunityChlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner +3 more
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Genomic Characteristics and Functional Analysis of Brucella sp. Strain WY7 Isolated from Antarctic Krill [PDF]
Microorganisms, 2023 Antarctic krill (Euphausia superba) is a key species of the Antarctic ecosystem whose unique ecological status and great development potential have attracted extensive attention.
Zhengqi Feng +6 more
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Correction to: Resonance assignments of a VapC family toxin from Clostridium thermocellum [PDF]
Biomolecular NMR Assignments, 2020 In the original publication of the article, the authors found a misquote in the Reference section.
Chen Wang +3 more
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